Metabotropic Glutamate Receptor 5 抗体 (Extracellular, N-Term)
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Quick Overview for Metabotropic Glutamate Receptor 5 抗体 (Extracellular, N-Term) (ABIN7043252)
抗原
See all Metabotropic Glutamate Receptor 5 (GRM5) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Extracellular, N-Term
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原理
- A Guinea Pig Polyclonal Antibody to Metabotropic Glutamate Receptor 5
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交叉反应
- 小鼠, 大鼠
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预测反应
- Mouse - identical, human - 13,14 amino residues identical
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产品特性
- Guinea pig Anti-mGluR5 (extracellular) Antibody is directed against an epitope of rat mGluR5. Guinea pig Anti-mGluR5 (extracellular) Antibody , raised in guinea pigs, can be used in western blot analysis. It has been designed to recognize mGluR5 from mouse, rat, and human samples. The antigen used to immunize guinea pigs is the same as Anti-mGluR5 (extracellular) Antibody (ABIN7043250, ABIN7044332 and ABIN7044333) raised in rabbit. Our line of guinea pig antibodies enables more flexibility with our products such as multiplex staining studies, immunoprecipitation, etc.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- EGFAQENSKYNKTC, corresponding to amino acids 367-380 of rat mGluR5
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亚型
- IgG
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anti-Glutamate Receptor, Metabotropic 5 (GRM5) (AA 458-580) antibody
GRM5 适用: 人 IHC, ELISA, ICC 宿主: 小鼠 Monoclonal 1A11D10 unconjugated
anti-Glutamate Receptor, Metabotropic 5 (GRM5) (Extracellular), (N-Term) antibodyGRM5 适用: 大鼠 WB, IHC, IF, FACS, IC, LCI 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 5 (GRM5) (AA 824-1203) antibody (Atto 390)GRM5 适用: 大鼠 WB, IHC, IF, ICC, IP 宿主: 小鼠 Monoclonal S75-3 Atto 390
anti-Glutamate Receptor, Metabotropic 5 (GRM5) (AA 824-1203) antibody (Atto 488)GRM5 适用: 大鼠 WB, IHC, IF, ICC, IP 宿主: 小鼠 Monoclonal S75-3 Atto 488
anti-Glutamate Receptor, Metabotropic 5 (GRM5) (AA 824-1203) antibody (Biotin)GRM5 适用: 大鼠 WB, IHC, IF, ICC, IP 宿主: 小鼠 Monoclonal S75-3 Biotin
anti-Glutamate Receptor, Metabotropic 5 (GRM5) (AA 824-1203) antibody (PerCP)GRM5 适用: 大鼠 WB, IHC, IF, ICC, IP 宿主: 小鼠 Monoclonal S75-3 PerCP
anti-Glutamate Receptor, Metabotropic 5 (GRM5) (AA 824-1203) antibody (Atto 594)GRM5 适用: 大鼠 WB, IHC, IF, ICC, IP 宿主: 小鼠 Monoclonal S75-3 Atto 594
anti-Glutamate Receptor, Metabotropic 5 (GRM5) (AA 824-1203) antibody (FITC)GRM5 适用: 大鼠 WB, IHC, IF, ICC, IP 宿主: 小鼠 Monoclonal S75-3 FITC
anti-Glutamate Receptor, Metabotropic 5 (GRM5) (AA 824-1203) antibody (APC)GRM5 适用: 大鼠 WB, IHC, IF, ICC, IP 宿主: 小鼠 Monoclonal S75-33 APC
anti-Glutamate Receptor, Metabotropic 5 (GRM5) (AA 824-1203) antibody (APC)GRM5 适用: 大鼠 WB, IHC, IF, ICC, IP 宿主: 小鼠 Monoclonal S75-3 APC
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应用备注
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WB: 1:400
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235697)
Blocking Peptide: (ABIN7235697)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Metabotropic Glutamate Receptor 5 (GRM5) (Glutamate Receptor, Metabotropic 5 (GRM5))
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别名
- GRM5
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背景
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Synonyms: Metabotropic glutamate receptor 5, GRM5, mGlu5, GPRC1E
Description: Metabotropic glutamate G protein-coupled receptors are divided into three groups on the basis of their sequence similarity, pharmacology and signal transduction mechanisms. mGluR5 is a class I mGlu receptor and is widely expressed throughout the cortex, hippocampus, striatum, caudate nucleus and nucleus accumbens, areas involved in emotion, motivation and cognition. mGluR5 is primarily located post-synaptically and is coupled to the Gq/11 pathway.mGluR5 is comprised of an extracellular N-terminus, an intracellular C-terminus and seven transmembrane α helices (TM1-7). Native ligands can bind to the receptor's extracellular domain. This extracellular binding is consistent with the narrow allosteric pocket the receptor possesses due to the tight configuration of its helical bundle1. mGluR5 is physically coupled to NMDA receptors by various scaffolding proteins including PSD-95, Shank, and Homer, as well as via a direct interaction. In addition, mGluR5 is biochemically coupled to NMDA receptor function via PKC. As a result of these molecular and biochemical interactions, activation of mGluR5 results in enhanced functionality of the NMDA receptor.mGluR5 is also involved in dendrogenesis and spineogenesis. mGluR5-/- knockout mice exhibit elevated spine densities irrespective of spine type or location along their dendritic trees in comparison to mGluR5+/- animals2.Recent studies have shown that mGluR5 is a critical mediator and a potential therapeutic target for the treatment of numerous disorders of the central nervous system, including depression, anxiety, drug addiction, chronic pain, Fragile X syndrome, Parkinson's disease, and gastroesophageal reflux disease3.
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基因ID
- 24418
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NCBI登录号
- NM_000842
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UniProt
- P31424
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途径
- Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of long-term Neuronal Synaptic Plasticity
抗原
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