Metabotropic Glutamate Receptor 5 抗体 (Extracellular, N-Term)
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Quick Overview for Metabotropic Glutamate Receptor 5 抗体 (Extracellular, N-Term) (ABIN7043250)
抗原
See all Metabotropic Glutamate Receptor 5 (GRM5) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to Metabotropic Glutamate Receptor 5
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse - identical, human - 13,14 amino residues identical
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产品特性
- Anti-mGluR5 (extracellular) Antibody (ABIN7043250, ABIN7044332 and ABIN7044333) is a highly specific antibody directed against an extracelluar epitope of rat mGluR5. The antibody can be used in western blot, immunohistochemistry, live cell imaging, and indirect live cell flow cytometry applications. It has been designed to recognize mGluR5 from rat, mouse, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- EGFAQENSKYNKTC, corresponding to amino acids 367-380 of rat mGluR5
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亚型
- IgG
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anti-Glutamate Receptor, Metabotropic 5 (GRM5) (AA 458-580) antibody
GRM5 适用: 人 IHC, ELISA, ICC 宿主: 小鼠 Monoclonal 1A11D10 unconjugated
anti-Glutamate Receptor, Metabotropic 5 (GRM5) (AA 824-1203) antibody (Atto 390)GRM5 适用: 大鼠 WB, IHC, IF, ICC, IP 宿主: 小鼠 Monoclonal S75-3 Atto 390
anti-Glutamate Receptor, Metabotropic 5 (GRM5) (AA 824-1203) antibody (Atto 488)GRM5 适用: 大鼠 WB, IHC, IF, ICC, IP 宿主: 小鼠 Monoclonal S75-3 Atto 488
anti-Glutamate Receptor, Metabotropic 5 (GRM5) (AA 824-1203) antibody (Biotin)GRM5 适用: 大鼠 WB, IHC, IF, ICC, IP 宿主: 小鼠 Monoclonal S75-3 Biotin
anti-Glutamate Receptor, Metabotropic 5 (GRM5) (AA 824-1203) antibody (PerCP)GRM5 适用: 大鼠 WB, IHC, IF, ICC, IP 宿主: 小鼠 Monoclonal S75-3 PerCP
anti-Glutamate Receptor, Metabotropic 5 (GRM5) (AA 824-1203) antibody (Atto 594)GRM5 适用: 大鼠 WB, IHC, IF, ICC, IP 宿主: 小鼠 Monoclonal S75-3 Atto 594
anti-Glutamate Receptor, Metabotropic 5 (GRM5) (AA 824-1203) antibody (FITC)GRM5 适用: 大鼠 WB, IHC, IF, ICC, IP 宿主: 小鼠 Monoclonal S75-3 FITC
anti-Glutamate Receptor, Metabotropic 5 (GRM5) (AA 824-1203) antibody (APC)GRM5 适用: 大鼠 WB, IHC, IF, ICC, IP 宿主: 小鼠 Monoclonal S75-33 APC
anti-Glutamate Receptor, Metabotropic 5 (GRM5) (AA 824-1203) antibody (APC)GRM5 适用: 大鼠 WB, IHC, IF, ICC, IP 宿主: 小鼠 Monoclonal S75-3 APC
anti-Glutamate Receptor, Metabotropic 5 (GRM5) (AA 824-1203) antibody (HRP)GRM5 适用: 大鼠 WB, IHC, IF, ICC, IP 宿主: 小鼠 Monoclonal S75-3 HRP
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应用备注
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WB: 1:500
FC: 5 μg per reaction
ICC: 1:100
IHC: 1:50
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235697)
Blocking Peptide: (ABIN7235697)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Metabotropic Glutamate Receptor 5 (GRM5) (Glutamate Receptor, Metabotropic 5 (GRM5))
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别名
- GRM5
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背景
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Synonyms: Metabotropic glutamate receptor 5, GRM5, mGlu5, GPRC1E
Description: L-Glutamate, the major excitatory neurotransmitter in the central nervous system, operates through several receptors that are categorized as ionotropic (ligand-gated cation channels) or metabotropic (G-protein coupled receptors). The metabotropic glutamate receptors family includes eight members (mGluR1-8) that have been divided into three groups based on their sequence homology, pharmacology and signal transduction.Group I of the metabotropic glutamate receptors includes the mGluR1 and mGluR5 receptors. The receptors present the typical G-protein coupled receptor (GPCR) signature topology: seven transmembrane domains with a large extracellular N-terminus domain and an intracellular C-terminus one. The N-terminus domain of group I receptors contains the glutamate binding site while the cytoplasmic C-terminus domain has an important role in the regulation of receptor activity through interactions with other proteins such as the Homer adaptor proteins.mGluR1 and mGluR5 receptors signal through Gq/G11 that activates phospholipase C and ultimately produces an increase in inositol trisphosphate and cytosolic Ca2+. More downstream signaling pathways include activation of PKC and modulation of Ca2+ and K+ ion channels. Activation of signaling pathways independent of G-proteins has also been reported.mGluR5 is predominantly expressed in nervous tissue although expression in several non-neural cell types has also been described. In the brain it is highly expressed in the cortex, basal ganglia and hippocampus.The mGluR5 receptor is involved in several physiological processes such as neuronal development, induction of long-term potentiation (LTP) and depression (LTD) as well as in pathological disorders such as brain trauma, chronic pain, Parkinson's and Huntington's disease.
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基因ID
- 24418
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NCBI登录号
- NM_000842
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UniProt
- P31424
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途径
- Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of long-term Neuronal Synaptic Plasticity
抗原
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