Metabotropic Glutamate Receptor 5 抗体 (Extracellular)
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- 抗原 See all Metabotropic Glutamate Receptor 5 (GRM5) 抗体
- Metabotropic Glutamate Receptor 5 (GRM5) (Glutamate Receptor, Metabotropic 5 (GRM5))
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抗原表位
- AA 367-380, Extracellular
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Metabotropic Glutamate Receptor 5 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunofluorescence (Cultured Cells) (IF (cc)), Immunochromatography (IC), Live Cell Imaging (LCI)
- 原理
- A Rabbit Polyclonal Antibody to Metabotropic Glutamate Receptor 5
- 特异性
- Extracellular, N-terminus
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Mouse - identical, human - 13,14 amino residues identical
- 产品特性
- Anti-mGluR5 (extracellular) Antibody (ABIN7043250, ABIN7044332 and ABIN7044333)) is a highly specific antibody directed against an extracelluar epitope of rat mGluR5. The antibody can be used in western blot, immunohistochemistry, live cell imaging, and indirect live cell flow cytometry applications. It has been designed to recognize mGluR5 from rat, mouse, and human samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: EGFAQENSKYNKTC, corresponding to amino acids 367-380 of rat mGluR5
- 亚型
- IgG
- Top Product
- Discover our top product GRM5 Primary Antibody
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anti-Glutamate Receptor, Metabotropic 5 (GRM5) (AA 458-580) antibody
GRM5 适用: 人 IHC, ELISA, ICC 宿主: 小鼠 Monoclonal 1A11D10 unconjugated
anti-Glutamate Receptor, Metabotropic 5 (GRM5) (AA 419-518) antibodyGRM5 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 1B3 unconjugated
anti-Glutamate Receptor, Metabotropic 5 (GRM5) (AA 824-1203) antibodyGRM5 适用: 大鼠 WB, IHC, IF, IP, ICC 宿主: 小鼠 Monoclonal S75-33 unconjugated
anti-Glutamate Receptor, Metabotropic 5 (GRM5) (AA 824-1203) antibodyGRM5 适用: 大鼠 WB, IHC, IF, IP, ICC 宿主: 小鼠 Monoclonal S75-3 unconjugated
anti-Glutamate Receptor, Metabotropic 5 (GRM5) (AA 824-1203) antibody (Alkaline Phosphatase (AP))GRM5 适用: 大鼠 WB, IHC, IF, IP, ICC 宿主: 小鼠 Monoclonal S75-3 Alkaline Phosphatase (AP)
anti-Glutamate Receptor, Metabotropic 5 (GRM5) (AA 824-1203) antibody (HRP)GRM5 适用: 大鼠 WB, IHC, IF, IP, ICC 宿主: 小鼠 Monoclonal S75-33 HRP
anti-Glutamate Receptor, Metabotropic 5 (GRM5) (AA 824-1203) antibody (HRP)GRM5 适用: 大鼠 WB, IHC, IF, IP, ICC 宿主: 小鼠 Monoclonal S75-3 HRP
anti-Glutamate Receptor, Metabotropic 5 (GRM5) (AA 824-1203) antibody (Biotin)GRM5 适用: 大鼠 WB, IHC, IF, IP, ICC 宿主: 小鼠 Monoclonal S75-33 Biotin
anti-Glutamate Receptor, Metabotropic 5 (GRM5) (AA 824-1203) antibody (Biotin)GRM5 适用: 大鼠 WB, IHC, IF, IP, ICC 宿主: 小鼠 Monoclonal S75-3 Biotin
anti-Glutamate Receptor, Metabotropic 5 (GRM5) (AA 824-1203) antibody (PE)GRM5 适用: 大鼠 WB, IHC, IF, IP, ICC 宿主: 小鼠 Monoclonal S75-33 PE
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:50
Application Dilutions Western blot wb: 1:500
- 说明
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Negative Control: BLP-GC007
Blocking Peptide: BLP-GC007
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- 0.2 mL double distilled water (DDW).
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- Metabotropic Glutamate Receptor 5 (GRM5) (Glutamate Receptor, Metabotropic 5 (GRM5))
- 别名
- GRM5 (GRM5 产品)
- 背景
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Metabotropic glutamate receptor 5, GRM5, mGlu5, GPRC1E,L-Glutamate, the major excitatory neurotransmitter in the central nervous system, operates through several receptors that are categorized as ionotropic (ligand-gated cation channels) or metabotropic (G-protein coupled receptors). The metabotropic glutamate receptors family includes eight members (mGluR1-8) that have been divided into three groups based on their sequence homology, pharmacology and signal transduction.Group I of the metabotropic glutamate receptors includes the mGluR1 and mGluR5 receptors. The receptors present the typical G-protein coupled receptor (GPCR) signature topology: seven transmembrane domains with a large extracellular N-terminus domain and an intracellular C-terminus one. The N-terminus domain of group I receptors contains the glutamate binding site while the cytoplasmic C-terminus domain has an important role in the regulation of receptor activity through interactions with other proteins such as the Homer adaptor proteins.mGluR1 and mGluR5 receptors signal through Gq/G11 that activates phospholipase C and ultimately produces an increase in inositol trisphosphate and cytosolic Ca2+. More downstream signaling pathways include activation of PKC and modulation of Ca2+ and K+ ion channels. Activation of signaling pathways independent of G-proteins has also been reported.mGluR5 is predominantly expressed in nervous tissue although expression in several non-neural cell types has also been described. In the brain it is highly expressed in the cortex, basal ganglia and hippocampus.The mGluR5 receptor is involved in several physiological processes such as neuronal development, induction of long-term potentiation (LTP) and depression (LTD) as well as in pathological disorders such as brain trauma, chronic pain, Parkinson's and Huntington's disease.
Alternative names: mGluR5, Metabotropic glutamate receptor 5, GRM5, mGlu5, GPRC1E - 基因ID
- 24418
- NCBI登录号
- NM_000842
- UniProt
- P31424
- 途径
- Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of long-term Neuronal Synaptic Plasticity
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