Metabotropic Glutamate Receptor 4 抗体 (Extracellular, N-Term)
Our Local Distributor
北京 101111
Quick Overview for Metabotropic Glutamate Receptor 4 抗体 (Extracellular, N-Term) (ABIN7043249)
抗原
See all Metabotropic Glutamate Receptor 4 (GRM4) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 33-44, Extracellular, N-Term
-
原理
- A Rabbit Polyclonal Antibody to Metabotropic Glutamate Receptor 4
-
交叉反应
- 人, 小鼠, 大鼠
-
预测反应
- Mouse,human - identical
-
产品特性
- Anti-mGluR4 (extracellular) Antibody is directed against an extracellular epitope of rat mGluR4. Anti-mGluR4 (extracellular) Antibody (ABIN7043249, ABIN7044344 and ABIN7044345) can be used in western blot and live cell imaging applications. It has been designed to recognize mGluR4 from rat, mouse and human samples.
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
- KPKGHPHMNSIR(C), corresponding to amino acid residues 33-44 of rat mGluR4
-
亚型
- IgG
-
-
anti-Glutamate Receptor, Metabotropic 4 (GRM4) (C-Term) antibody
GRM4 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 4 (GRM4) (C-Term) antibodyGRM4 适用: 人, 小鼠, 猴, Pig, 兔 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 4 (GRM4) (C-Term) antibodyGRM4 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 4 (GRM4) (C-Term) antibodyGRM4 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 4 (GRM4) (N-Term) antibodyGRM4 适用: 人, 大鼠, 小鼠, 猴, Pig, 兔, Cow, 犬, 马 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 4 (GRM4) (AA 820-900) antibodyGRM4 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 4 (GRM4) (C-Term) antibodyGRM4 适用: 人, 大鼠, 小鼠, 猴, 小鸡 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 4 (GRM4) (AA 33-290) antibodyGRM4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 4 (GRM4) (AA 851-900) antibodyGRM4 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: 1:50
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
-
说明
-
Negative Control: (ABIN7235693)
Blocking Peptide: (ABIN7235693)
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
-
浓度
- 0.8 mg/mL
-
缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
-
-
- Metabotropic Glutamate Receptor 4 (GRM4) (Glutamate Receptor, Metabotropic 4 (GRM4))
-
别名
- GRM4
-
背景
-
Synonyms: Metabotropic glutamate receptor 4, GRM4, mGlu4, GPRC1D
Description: Metabotropic glutamate receptors (mGluRs) belong to the super family of G-protein coupled receptors (seven transmembrane proteins). mGluRs are further divided into subfamilies: group I mGluRs (mGluR1 and mGluR5) which couple to Gq, thereby activating phospholipase C (PLC). Group II which include mGluR2 and mGluR3 couple to Gi, therefore inhibit the formation of adenylate cyclase. mGluR4, 6, 7, 8 which belong to group III also inhibit adenylate cyclase formation by coupling to Gi1.The C-terminus of these receptors has important functions in modulating their activity. This region is important for G-protein coupling, post-translational modifications like phosphorylation as well as protein-protein interactions. The C-terminal region is also subject to alternative splicing2.mGluR4 is predominantly expressed presynaptically in neurons and in the cerebellum. A splice variant of the protein is expressed in taste buds. This variant lacks a large portion of the N-terminus and is normally referred to taste mGluR43,4. It is responsible (along with taste mGluR1) for mediating the taste of monosodium glutamate (or unami)2,4.mGluR4 knock out mice display impaired cerebellar synaptic plasticity as well as some learning disabilities5. In addition, this receptor has emerged as a target for the treatment of Parkinson's disease6.
-
基因ID
- 24417
-
NCBI登录号
- NM_000841
-
UniProt
- P31423
抗原
-
