Metabotropic Glutamate Receptor 4 抗体 (Extracellular)
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- 抗原 See all Metabotropic Glutamate Receptor 4 (GRM4) 抗体
- Metabotropic Glutamate Receptor 4 (GRM4) (Glutamate Receptor, Metabotropic 4 (GRM4))
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抗原表位
- AA 33-44, Extracellular
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Metabotropic Glutamate Receptor 4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Immunochromatography (IC), Live Cell Imaging (LCI)
- 原理
- A Rabbit Polyclonal Antibody to Metabotropic Glutamate Receptor 4
- 特异性
- Extracellular, N-terminus
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Mouse,human - identical
- 产品特性
- Anti-mGluR4 (extracellular) Antibody is directed against an extracellular epitope of rat mGluR4. Anti-mGluR4 (extracellular) Antibody (ABIN7043249, ABIN7044344 and ABIN7044345)) can be used in western blot and live cell imaging applications. It has been designed to recognize mGluR4 from rat, mouse and human samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: KPKGHPHMNSIR(C), corresponding to amino acid residues 33-44 of rat mGluR4
- 亚型
- IgG
- Top Product
- Discover our top product GRM4 Primary Antibody
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anti-Glutamate Receptor, Metabotropic 4 (GRM4) (C-Term) antibody
GRM4 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 4 (GRM4) (C-Term) antibodyGRM4 适用: 人, 小鼠, 猴, Pig, 兔 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 4 (GRM4) (C-Term) antibodyGRM4 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 4 (GRM4) (N-Term) antibodyGRM4 适用: 人, 小鼠, 大鼠, 猴, Pig, 兔, Cow, 犬, 马 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 4 (GRM4) (C-Term) antibodyGRM4 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 4 (GRM4) (C-Term) antibodyGRM4 适用: 人, 小鼠, 大鼠, 猴, 小鸡 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 4 (GRM4) (AA 33-290) antibodyGRM4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 4 (GRM4) (AA 851-900) antibodyGRM4 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
- 说明
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Negative Control: BLP-GC014
Blocking Peptide: BLP-GC014
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- Metabotropic Glutamate Receptor 4 (GRM4) (Glutamate Receptor, Metabotropic 4 (GRM4))
- 别名
- GRM4 (GRM4 产品)
- 背景
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Metabotropic glutamate receptor 4, GRM4, mGlu4, GPRC1D,Metabotropic glutamate receptors (mGluRs) belong to the super family of G-protein coupled receptors (seven transmembrane proteins). mGluRs are further divided into subfamilies: group I mGluRs (mGluR1 and mGluR5) which couple to Gq, thereby activating phospholipase C (PLC). Group II which include mGluR2 and mGluR3 couple to Gi, therefore inhibit the formation of adenylate cyclase. mGluR4, 6, 7, 8 which belong to group III also inhibit adenylate cyclase formation by coupling to Gi1.The C-terminus of these receptors has important functions in modulating their activity. This region is important for G-protein coupling, post-translational modifications like phosphorylation as well as protein-protein interactions. The C-terminal region is also subject to alternative splicing2.mGluR4 is predominantly expressed presynaptically in neurons and in the cerebellum. A splice variant of the protein is expressed in taste buds. This variant lacks a large portion of the N-terminus and is normally referred to taste mGluR43,4. It is responsible (along with taste mGluR1) for mediating the taste of monosodium glutamate (or unami)2,4.mGluR4 knock out mice display impaired cerebellar synaptic plasticity as well as some learning disabilities5. In addition, this receptor has emerged as a target for the treatment of Parkinson's disease6.
Alternative names: mGluR4, Metabotropic glutamate receptor 4, GRM4, mGlu4, GPRC1D - 基因ID
- 24417
- NCBI登录号
- NM_000841
- UniProt
- P31423
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