GRIK2 抗体 (Intracellular)
Quick Overview for GRIK2 抗体 (Intracellular) (ABIN7043238)
抗原
See all GRIK2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Intracellular
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原理
- A Rabbit Polyclonal Antibody to Kainate Receptor GluK2
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特异性
- Intracellular, C-terminus
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Human,mouse,dog - identical
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产品特性
- Anti-GRIK2 (GluK2) Antibody (ABIN7043238, ABIN7044336 and ABIN7044337) is directed against the intracellular C-terminus domain of the rat kainate receptor GluK2. The antibody can be used in western blot and immunofluorescence applications and will recognize GluR6 from rat, human and mouse origins.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: CSAMVEELRMSLK, corresponding to amino acid residues 858-870 of rat kainate receptor GluK2
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亚型
- IgG
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anti-Glutamate Receptor, Ionotropic, Kainate 2 (GRIK2) antibody
GRIK2 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Glutamate Receptor, Ionotropic, Kainate 2 (GRIK2) (AA 30-300) antibodyGRIK2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, Kainate 2 (GRIK2) (AA 45-226) antibodyGRIK2 适用: 人 ELISA 宿主: 小鼠 Monoclonal 8A1F11 unconjugated
anti-Glutamate Receptor, Ionotropic, Kainate 2 (GRIK2) (N-Term) antibodyGRIK2 适用: 人, 小鼠, 大鼠, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, Kainate 2 (GRIK2) (N-Term) antibodyGRIK2 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, Kainate 2 (GRIK2) (AA 286-561) antibodyGRIK2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, Kainate 2 (GRIK2) (AA 203-500) antibodyGRIK2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, Kainate 2 (GRIK2) (AA 652-701) antibodyGRIK2 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, Bat, 小鸡, 猴, Pig, 非洲爪蟾 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, Kainate 2 (GRIK2) (AA 1-583) antibodyGRIK2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, Kainate 2 (GRIK2) (AA 151-200) antibodyGRIK2 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, Bat, 小鸡, 猴, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:400
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说明
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Negative Control: (ABIN7235657)
Blocking Peptide: (ABIN7235657)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- GRIK2 (Glutamate Receptor, Ionotropic, Kainate 2 (GRIK2))
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别名
- GRIK2
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背景
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Glutamate receptor ionotropic kainate 2, Glutamate receptor 6, GluR6, GLUK6,L-Glutamate, the major excitatory neurotransmitter in the central nervous system (CNS), operates through several receptors that are categorized as ionotropic (ligand-gated cation channels) or metabotropic (G-protein-coupled receptors).The ligand-gated ion channel family consists of fifteen members that have been subdivided into three families based upon their pharmacological profile: the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-preferring receptors, the N-methyl-D-aspartate (NMDA)-preferring receptors, and the kainate-preferring receptors.The kainate receptor subfamily consists of five members that have been further subdivided into two classes based upon structural homology and functional characteristics. GluR5, GluR6, and GluR7 receptor subunits share a high degree of homology and are able to form functional channels when expressed in heterologous systems. The KA-1 and KA-2 receptors are unable to form functional channels on their own, but when coexpressed with GluR5-7 receptor subunits, they form channels with high affinity for kainate.1,2Like AMPA receptors, the functional unit of endogenous kainate receptors is believed to be a tetramer, which can be either homomeric or heteromeric. Kainate receptors GluR5 and GluR6 (but not GluR7, KA-1, or KA-2) can undergo RNA editing, as in the AMPA receptor GluR2, a glutamine (Q) residue in the channel pore is edited to encode arginine (R) in the mature protein. Substitution of Q with R modulates the properties of the channel, producing channels with reduced single channel conductance and lower permeability to Ca2+.1,2GluR6 is expressed in the CNS in basal ganglia, cerebellum, and hipoccampus, as well as in the spinal cord. The exact physiological role of GluR6 is unclear, but a role in controlling neuronal excitability, synaptic integration, and synaptic plasticity has been proposed.
Alternative names: GRIK2 (GluK2), Glutamate receptor ionotropic kainate 2, Glutamate receptor 6, GluR6, GLUK6 -
基因ID
- 54257
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NCBI登录号
- NM_001166247
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UniProt
- P42260
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途径
- Synaptic Membrane, Regulation of long-term Neuronal Synaptic Plasticity
抗原
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