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GRIK2 抗体 (Intracellular)

This anti-GRIK2 antibody is a 兔 多克隆 antibody detecting GRIK2 in WB, IF 和 IC. Suitable for 大鼠.
产品编号 ABIN7043238
发货至: 中国

Quick Overview for GRIK2 抗体 (Intracellular) (ABIN7043238)

抗原

See all GRIK2 抗体
GRIK2 (Glutamate Receptor, Ionotropic, Kainate 2 (GRIK2))

适用

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大鼠

宿主

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克隆类型

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多克隆

标记

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This GRIK2 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunofluorescence (IF), Immunochromatography (IC)
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    Intracellular

    原理

    A Rabbit Polyclonal Antibody to Kainate Receptor GluK2

    特异性

    Intracellular, C-terminus

    交叉反应

    人, 小鼠, 大鼠

    预测反应

    Human,mouse,dog - identical

    产品特性

    Anti-GRIK2 (GluK2) Antibody (ABIN7043238, ABIN7044336 and ABIN7044337) is directed against the intracellular C-terminus domain of the rat kainate receptor GluK2. The antibody can be used in western blot and immunofluorescence applications and will recognize GluR6 from rat, human and mouse origins.

    纯化方法

    Affinity purified on immobilized antigen.

    免疫原

    Immunogen: Synthetic peptide

    Immunogen Sequence: CSAMVEELRMSLK, corresponding to amino acid residues 858-870 of rat kainate receptor GluK2

    亚型

    IgG
  • 应用备注

    Antigen preadsorption control: 1 μg peptide per 1 μg antibody

    Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

    Application Dilutions Western blot wb: 1:400

    说明

    Negative Control: (ABIN7235657)

    Blocking Peptide: (ABIN7235657)

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    0.2 mL double distilled water (DDW).

    浓度

    1 mg/mL

    缓冲液

    PBS pH 7.4

    储存条件

    4 °C,-20 °C

    储存方法

    Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

    Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

  • 抗原

    GRIK2 (Glutamate Receptor, Ionotropic, Kainate 2 (GRIK2))

    别名

    GRIK2

    背景

    Glutamate receptor ionotropic kainate 2, Glutamate receptor 6, GluR6, GLUK6,L-Glutamate, the major excitatory neurotransmitter in the central nervous system (CNS), operates through several receptors that are categorized as ionotropic (ligand-gated cation channels) or metabotropic (G-protein-coupled receptors).The ligand-gated ion channel family consists of fifteen members that have been subdivided into three families based upon their pharmacological profile: the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-preferring receptors, the N-methyl-D-aspartate (NMDA)-preferring receptors, and the kainate-preferring receptors.The kainate receptor subfamily consists of five members that have been further subdivided into two classes based upon structural homology and functional characteristics. GluR5, GluR6, and GluR7 receptor subunits share a high degree of homology and are able to form functional channels when expressed in heterologous systems. The KA-1 and KA-2 receptors are unable to form functional channels on their own, but when coexpressed with GluR5-7 receptor subunits, they form channels with high affinity for kainate.1,2Like AMPA receptors, the functional unit of endogenous kainate receptors is believed to be a tetramer, which can be either homomeric or heteromeric. Kainate receptors GluR5 and GluR6 (but not GluR7, KA-1, or KA-2) can undergo RNA editing, as in the AMPA receptor GluR2, a glutamine (Q) residue in the channel pore is edited to encode arginine (R) in the mature protein. Substitution of Q with R modulates the properties of the channel, producing channels with reduced single channel conductance and lower permeability to Ca2+.1,2GluR6 is expressed in the CNS in basal ganglia, cerebellum, and hipoccampus, as well as in the spinal cord. The exact physiological role of GluR6 is unclear, but a role in controlling neuronal excitability, synaptic integration, and synaptic plasticity has been proposed.

    Alternative names: GRIK2 (GluK2), Glutamate receptor ionotropic kainate 2, Glutamate receptor 6, GluR6, GLUK6

    基因ID

    54257

    NCBI登录号

    NM_001166247

    UniProt

    P42260

    途径

    Synaptic Membrane, Regulation of long-term Neuronal Synaptic Plasticity
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