GRIK1 抗体 (Extracellular)
Quick Overview for GRIK1 抗体 (Extracellular) (ABIN7043237)
抗原
See all GRIK1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Extracellular
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原理
- A Rabbit Polyclonal Antibody to Kainate Receptor GluK1
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特异性
- Extracellular, N-terminus
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预测反应
- Human,dog,monkey - 15,16 amino acid residues identical
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产品特性
- Anti-GRIK1 (GluK1) (extracellular) Antibody (ABIN7043237, ABIN7044334 and ABIN7044335) is directed against the extracellular N-terminus domain of the rat kainate receptor GluK1. The antibody can be used in western blot and immunofluorescence applications.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)KASGEVSKHLYKVWKK, corresponding to amino acid residues 402-417 of rat kainate receptor GluK1
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亚型
- IgG
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anti-Glutamate Receptor, Ionotropic, Kainate 1 (GRIK1) (AA 675-834) antibody
GRIK1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, Kainate 1 (GRIK1) (Internal Region) antibodyVerified GRIK1 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, Kainate 1 (GRIK1) (AA 331-440) antibodyGRIK1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, Kainate 1 (GRIK1) (AA 271-450) antibodyGRIK1 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, Kainate 1 (GRIK1) (AA 10-59) antibodyGRIK1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, Kainate 1 (GRIK1) (Center) antibodyGRIK1 适用: 人, 大鼠, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, Kainate 1 (GRIK1) (C-Term) antibodyGRIK1 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:400
Application Dilutions Western blot wb: 1:200
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说明
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Negative Control: (ABIN7235653)
Blocking Peptide: (ABIN7235653)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- GRIK1 (Glutamate Receptor, Ionotropic, Kainate 1 (GRIK1))
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别名
- GRIK1
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背景
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Glutamate receptor ionotropic kainate 1, Glutamate receptor 5, GluR5,L-Glutamate, the major excitatory neurotransmitter in the central nervous system (CNS), operates through several receptors that are categorized as ionotropic (ligand-gated cation channels) or metabotropic (G-protein-coupled receptors).The ligand-gated ion channel family consists of fifteen members that have been subdivided into three families based upon their pharmacological profile: the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-preferring receptors, the N-methyl-D-aspartate (NMDA)-preferring receptors, and the kainate-preferring receptors.The kainate receptor subfamily consists of five members that have been further subdivided into two classes based upon structural homology and functional characteristics. GluR5, GluR6, and GluR7receptor subunits share a high degree of homology and are able to form functional channels when expressed in heterologous systems. The KA-1 and KA-2 receptors are unable to form functional channels on their own, but when coexpressed with GluR5-7 receptor subunits, they form channels with high affinity for kainate.1,2Like AMPA receptors, the functional unit of endogenous kainate receptors is believed to be a tetramer, which can be either homomeric or heteromeric. Kainate receptors GluR5 and GluR6 (but not GluR7, KA-1, or KA-2) can undergo RNA editing, as in the AMPA receptor GluR2, a glutamine (Q) residue in the channel pore is edited to encode arginine (R) in the mature protein. Substitution of Q with R modulates the properties of the channel, producing channels with reduced single channel conductance and lower permeability to Ca2+.1,2GluR5 is highly expressed in dorsal root ganglion (DRG) neurons of the peripheral nervous system (PNS) as well as in several structures of the CNS including the amygdala, the hipoccampus, and Purkinje cells of the cerebellum.GluR5 has been implicated in the modulation of synaptic transmission and synaptic plasticity in both the CNS and PNS, but the exact physiological function of GluR5 is not well understood. Nevertheless, an involvement in persistent pain and some types of learning has been proposed.
Alternative names: GRIK1 (GluK1), Glutamate receptor ionotropic kainate 1, Glutamate receptor 5, GluR5 -
基因ID
- 29559
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NCBI登录号
- NM_000830
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UniProt
- P22756
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途径
- Synaptic Membrane, Regulation of long-term Neuronal Synaptic Plasticity
抗原
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