GFRA3 抗体 (Extracellular)
Quick Overview for GFRA3 抗体 (Extracellular) (ABIN7043212)
抗原
See all GFRA3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 172-185, Extracellular
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原理
- A Rabbit Polyclonal Antibody to GDNF Family Receptor α3
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特异性
- Extracellular, N-terminus
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交叉反应
- 小鼠, 大鼠
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预测反应
- Mouse,rat,human - 13,14 amino acid residues identical
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产品特性
- Anti-GFR alpha 3 (extracellular) Antibody (ABIN7043212, ABIN7044779 and ABIN7044780) is a highly specific antibody directed against an epitope of mouse GDNF receptor α3. The antibody can be used in western blot analysis. It has been designed to recognize GFR α3 from human, mouse, and rat samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: CDRLRKAYGEA(S)SG, corresponding to amino acid residues 172-185 of mouse GFRA3
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亚型
- IgG
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anti-GDNF Family Receptor alpha 3 (GFRA3) (AA 32-236) antibody
GFRA3 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-GDNF Family Receptor alpha 3 (GFRA3) antibodyGFRA3 适用: 人 ELISA, WB, IF 宿主: 小鸡 Polyclonal unconjugated
anti-GDNF Family Receptor alpha 3 (GFRA3) (AA 32-240) antibodyGFRA3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-GDNF Family Receptor alpha 3 (GFRA3) (Intermediate Domain) antibodyGFRA3 适用: 人, 小鼠, 大鼠 WB, EIA, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
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说明
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Negative Control: (ABIN7235580)
Blocking Peptide: (ABIN7235580)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- GFRA3 (GDNF Family Receptor alpha 3 (GFRA3))
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别名
- GFRA3
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背景
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GFRA3, GFRα3, GDNF family receptor α3, GDNF receptor alpha 3,GFRα3 (GDNF Family Receptor α3) belongs to the glial cell line derived neurotrophic factor (GDNF) family of receptors which contains four members GFRα1-4. The GDNF family of ligands (GFLs)- GDNF, Neurturin, Artemin, and Persephin bind to co-receptors GFRα1-4 and activate Ret receptor tyrosine kinase. GDNF-family receptor α is glycosyl-phosphatidylinositol anchored to the cell surface. GFRα3 structure contains three homologous domains (D1, D2 and D3) and a C-terminal extension1-4.GFRα3 is a highly selective receptor for Artemin (Artn). Artemin is a vasculature-derived neurotrophic factor that modulates the development and function of sensory neurons and participates in the pathophysiology of peripheral inflammation and pain hyperalgesia.In adults, GFRα3 is restricted to neurons of the peripheral nervous system. The protein is expressed by a subpopulation of nociceptive sensory neurons which also express the Ret receptor tyrosine kinase, TRPV1, TRPA11,2,3.
Alternative names: GFR alpha 3, GFRA3, GFRalpha3, GDNF family receptor alpha3, GDNF receptor alpha 3 -
基因ID
- 14587
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NCBI登录号
- NM_001496
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UniProt
- O35118
抗原
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