GFRA1 抗体 (Extracellular Domain)
Our Local Distributor
北京 101111
Quick Overview for GFRA1 抗体 (Extracellular Domain) (ABIN7043211)
抗原
See all GFRA1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 72-83, Extracellular Domain
-
原理
- A Rabbit Polyclonal Antibody to GDNF Family Receptor α1
-
交叉反应
- 人, 小鼠, 大鼠
-
预测反应
- Mouse,human - identical
-
产品特性
- Anti-GFR alpha 1 (extracellular) Antibody is directed against an extracellular epitope of rat GDNF receptor α1. Anti-GFR alpha 1 (extracellular) Antibody (ABIN7043211, ABIN7044777 and ABIN7044778) can be used in western blot, immunohistochemistry, immunocytochemistry and live cell imaging applications. It has been designed to recognize GFR α1 from mouse, rat and human samples.
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
- CRSAMEALKQKS, corresponding to amino acid residues 72-83 of rat GFRA1
-
亚型
- IgG
-
-
anti-GDNF Family Receptor alpha 1 (GFRA1) (AA 239-350) antibody
GFRA1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-GDNF Family Receptor alpha 1 (GFRA1) (AA 25-280) antibodyGFRA1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-GDNF Family Receptor alpha 1 (GFRA1) (AA 351-429) antibodyGFRA1 适用: 人, 小鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-GDNF Family Receptor alpha 1 (GFRA1) (AA 230-385) antibodyGFRA1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-GDNF Family Receptor alpha 1 (GFRA1) (AA 32-119) antibodyGFRA1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1G4 unconjugated
anti-GDNF Family Receptor alpha 1 (GFRA1) (AA 32-119) antibodyGFRA1 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 4D8 unconjugated
anti-GDNF Family Receptor alpha 1 (GFRA1) (AA 369-382) antibodyGFRA1 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-GDNF Family Receptor alpha 1 (GFRA1) antibodyGFRA1 适用: 人 WB, ELISA, IF 宿主: 小鸡 Polyclonal unconjugated
anti-GDNF Family Receptor alpha 1 (GFRA1) (AA 25-227) antibodyGFRA1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: 1:50
IHC: 1:100
IP: The optimal concentration should be determined by the user
-
说明
-
Negative Control: (ABIN7235577)
Blocking Peptide: (ABIN7235577)
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
-
浓度
- 0.8 mg/mL
-
缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
-
-
- GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))
-
别名
- GFRA1
-
背景
-
Synonyms: GFRA1, GFRα1, GDNF family receptor α1, GDNF receptor alpha 1, Ret ligand 1, RETL1, TRNR1
Description: The GDNF family ligands (GFLs) belong to the super family of the TGF-β. They belong to the group of cystine-knot protein and function as homodimers1. This family includes glial cell line-derived neurotrophic factor (GDNF), artemin (ARTN), Neurturin (NRTN) and persephin (PSPN)2.These factors are heavily involved in the development and function of the nervous system (both central and peripheral). In particular GDNF has an important role outside the nervous system where it plays a role in kidney morphogenesis1.In general GFLs all signal through a signal through the receptor tyrosine kinase Ret. Their specificity is implemented by different GDNF family receptor a (GFRα), which act as co-receptors. These extracellular proteins are bound to the plasma membrane via a glycosyl phosphatidyl inositol (GPI) anchor. GFRα1-4 are responsible for the binding of GDNF, NRTN, ARTN, and PSPN respectively and the subsequent activation of Ret. Soluble forms of the receptor by the cleavage of a yet unknown phospholipase or protease can be detected1,3. Also alternative spliced forms of the protein can lead to soluble forms of GFRα receptors3. In respect to their important role in development, individual knockout of either gdnf, gfra1 or ret gives rise to lethal phenotypes2.
-
基因ID
- 25454
-
NCBI登录号
- NM_145793
-
UniProt
- Q62997
抗原
-
