GRPR 抗体 (Extracellular)
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- 抗原 See all GRPR 抗体
- GRPR (Gastrin-Releasing Peptide Receptor (GRPR))
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抗原表位
- AA 287-300, Extracellular
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This GRPR antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC), Live Cell Imaging (LCI)
- 原理
- A Rabbit Polyclonal Antibody to Bombesin Receptor 2/Gastrin-releasing Peptide Receptor
- 特异性
- 3rd extracellular loop
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Rat,mouse,dog - identical
- 产品特性
- Anti-Bombesin Receptor 2 (GRPR) (extracellular) Antibody is directed against an epitope located in the 3rd extracellular loop of the human BB2 receptor (gastrin-releasing peptide receptor). Anti-Bombesin Receptor 2 (extracellular) (GRPR) Antibody (ABIN7043210 and ABIN7043937)) can be used in western blot analysis, as well as immunocytochemical and immunohistochemical applications, and will recognize BB2R from human, rat, mouse, and dog samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)RSYHYSEVDTSMLH, corresponding to amino acid residues 287-300 of human BB2R
- 亚型
- IgG
- Top Product
- Discover our top product GRPR Primary Antibody
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anti-Gastrin-Releasing Peptide Receptor (GRPR) (AA 326-384) antibody
GRPR 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Gastrin-Releasing Peptide Receptor (GRPR) antibodyGRPR 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Gastrin-Releasing Peptide Receptor (GRPR) (AA 235-384) antibodyGRPR 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Gastrin-Releasing Peptide Receptor (GRPR) antibodyGRPR 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Gastrin-Releasing Peptide Receptor (GRPR) (Extracellular Domain) antibodyGRPR 适用: 人, Bat, 犬, 猴, Pig, 马, 兔 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Gastrin-Releasing Peptide Receptor (GRPR) antibodyGRPR 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Gastrin-Releasing Peptide Receptor (GRPR) (AA 130-160), (Middle Region) antibodyGRPR 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Gastrin-Releasing Peptide Receptor (GRPR) (Cytoplasmic Domain) antibodyGRPR 适用: 人, 小鼠, 大鼠, Bat, 犬, 猴, Pig, Cow, Hamster IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Gastrin-Releasing Peptide Receptor (GRPR) (Internal Region) antibodyGRPR 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Gastrin-Releasing Peptide Receptor (GRPR) (AA 1-114) antibodyGRPR 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:50
Application Dilutions Western blot wb: 1:200-1:500
- 说明
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Cited Application: IHC
Negative Control: BLP-BR002
Blocking Peptide: BLP-BR002
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- 0.2 mL double distilled water (DDW).
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- GRPR (Gastrin-Releasing Peptide Receptor (GRPR))
- 别名
- GRPR (GRPR 产品)
- 背景
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BB2R, Gastrin-releasing peptide receptor, GRP-preferring bombesin receptor,Bombesin receptor 2 (BB2) is a member of a family of receptors that binds the 14 amino acid peptide, bombesin. Bombesin was first isolated from frog skin and it was later established that mammals express endogenous bombesin-like peptides such as gastrin-releasing peptide (GRP, a 27 amino acid homologue) and neuromedin B (NMB, a 10 amino acid homologue).BB2 is the preferred receptor for GRP and hence it is also referred to as GRP receptor or GRP-R.1 BB1 is the preferred receptor for NMB and therefore it is also known as NMB-R. A third member (called BB3) of the bombesin receptor family has been recognized but the endogenous mammalian ligand for this receptor remains to be identified.All three bombesin receptors are members of the seven-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. BB2 is coupled to a Gq/11 protein that activates phospholipase C (PLC) and leads to production of inositol 1,4,5-trisphosphate (InsP3), intracellular Ca2+ mobilization, and cell growth.2GRP (through its binding to BB2) plays an essential role in the release of hormones in the intestinal tract, the regulation of smooth muscle contraction, and the secretion of pancreatic enzymes.2 In the brain, BB2 has been implicated in regulating feeding behavior, thermoregulation, and memory formation.3Finally, BB2 is overexpressed in several human tumors including breast, prostate, and lung, where it acts as a growth factor receptor inducing tumor growth. BB2 is considered a potential target for the development of both diagnostics and anti-cancer therapies.4
Alternative names: Bombesin Receptor 2 (GRPR), BB2R, Gastrin-releasing peptide receptor, GRP-preferring bombesin receptor - 基因ID
- 2925
- NCBI登录号
- NM_005314
- UniProt
- P30550
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