GJD2 抗体 (Intracellular)
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Quick Overview for GJD2 抗体 (Intracellular) (ABIN7043205)
抗原
See all GJD2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 170-182, Intracellular
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原理
- A Rabbit Polyclonal Antibody to Connexin-36
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交叉反应
- 小鼠, 大鼠
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预测反应
- Mouse,human - 12,13 amino acid residues identical
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产品特性
- Anti-Connexin-36 Antibody (ABIN7043205, ABIN7044087 and ABIN7044088) is a highly specific antibody targeted against an epiotpe of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize Cx36 from human, rat, and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)EVKELAPHPSGLR, corresponding to amino acid residues 170-182 of rat Connexin-36
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亚型
- IgG
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anti-Gap Junction Protein, delta 2, 36kDa (GJD2) (AA 99-197) antibody
GJD2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, delta 2, 36kDa (GJD2) (Middle Region) antibodyGJD2 适用: 人, 大鼠, 小鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, delta 2, 36kDa (GJD2) (AA 99-197) antibodyGJD2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5E5 unconjugated
anti-Gap Junction Protein, delta 2, 36kDa (GJD2) (AA 201-321) antibodyGJD2 适用: 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, delta 2, 36kDa (GJD2) (Middle Region) antibodyGJD2 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, delta 2, 36kDa (GJD2) (AA 159-208) antibodyGJD2 适用: 人, 大鼠, 小鼠, Cow, 犬, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, delta 2, 36kDa (GJD2) (AA 131-180) antibodyGJD2 适用: 人, 大鼠, 小鼠, Cow, 犬, 豚鼠, 马, 兔, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, delta 2, 36kDa (GJD2) (C-Term) antibodyGJD2 适用: 人, 大鼠, 小鼠, Cow, 犬, 豚鼠, 马, 兔, 猴, Pig, Bat, Hamster, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, delta 2, 36kDa (GJD2) (AA 292-321), (C-Term) antibodyGJD2 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, delta 2, 36kDa (GJD2) (AA 291-321), (C-Term) antibodyGJD2 适用: 人, 大鼠, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:300
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235554)
Blocking Peptide: (ABIN7235554)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- GJD2 (Gap Junction Protein, delta 2, 36kDa (GJD2))
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别名
- GJD2
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背景
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Synonyms: CX36, Gap junction δ2 protein, Gap junction α9 protein, GJD2, GJA9
Description: The structural unit of the gap junctions is the connexon. Connexons are hexameric structures, formed by transcellular channels composed of connexins. Connexins (Cx) share a common structural basis, which is a four-transmembrane spanning protein, a cytoplasmic loop, two extracellular loops (E1-E2), one intracellular amino-(NT domain) and a carboxy-terminal (CT domain) region1.Connexin 36 (Cx36) is predominantly expressed in mammalian neuronal cells2. Cx36 is expressed in a variety of mammalian brain regions, but expression is particularly notable in the inferior olive, cerebellar cortex, olfactory bulbs, several brainstem nuclei, the CA3 subregion of the hippocampus and reticular thalamic nuclei3. Outside of the central nervous system, Cx36 also appears in motoneurons of adult rat spinal cord 4.Studies have shown that Cx36 is involved in some neural functions, including neuronal neurogenesis, neural fertility control and regulation of waking and sleep states, and also Cx36 plays an important role in N-methyl-D-aspartate-mediated neuronal death following neuronal injury5. A number of studies performed in humans and animals have confirmed the role of Cx36 in the generation and maintenance of seizure activity6.
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基因ID
- 50564
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NCBI登录号
- NM_020660
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UniProt
- O70610
抗原
-
