GJA4 抗体 (AA 131-144)
Quick Overview for GJA4 抗体 (AA 131-144) (ABIN7043200)
抗原
See all GJA4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 131-144
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原理
- A Rabbit Polyclonal Antibody to Connexin-37
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特异性
- Intracellular loop
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse - identical, human - 13,14 amino acid residues identical
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产品特性
- Anti-Connexin-37 Antibody is directed against an epitope of rat Connexin-37. Anti-Connexin-37 Antibody (ABIN7043200, ABIN7044081 and ABIN7044082) can be used in western blot analysis. It has been designed to recognize Cx37 from rat, mouse and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)EHQMAKISVAEDGR, corresponding to amino acid residues 131-144 of rat Connexin-37
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亚型
- IgG
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anti-Gap Junction Protein, alpha 4, 37kDa (GJA4) (AA 151-250) antibody
GJA4 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, alpha 4, 37kDa (GJA4) (Middle Region) antibodyGJA4 适用: 人, 小鼠, 大鼠, Cow, 兔, 绵羊, 犬, 豚鼠, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, alpha 4, 37kDa (GJA4) (AA 231-333) antibodyGJA4 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, alpha 4, 37kDa (GJA4) (AA 19-245) antibodyGJA4 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, alpha 4, 37kDa (GJA4) (AA 79-328) antibodyGJA4 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, alpha 4, 37kDa (GJA4) (N-Term) antibodyGJA4 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, alpha 4, 37kDa (GJA4) (AA 101-150) antibodyGJA4 适用: 小鼠, 大鼠, Hamster WB 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, alpha 4, 37kDa (GJA4) (AA 108-157) antibodyGJA4 适用: 人, 小鼠, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, alpha 4, 37kDa (GJA4) (AA 229-333) antibodyGJA4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, alpha 4, 37kDa (GJA4) (N-Term) antibodyGJA4 适用: 人, 小鼠, 大鼠, Cow, 犬, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200-1:400
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说明
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Negative Control: (ABIN7235535)
Blocking Peptide: (ABIN7235535)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- GJA4 (Gap Junction Protein, alpha 4, 37kDa (GJA4))
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别名
- GJA4
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背景
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CX37, Gap junction α4 protein, GJA4,Connexins (Cxs) are a family of transmembrane proteins comprising 21 members in humans that forms gap junction channels (GJCs). Connexins are divided in four groups: α, β, γ and δ. Cx37 is also named α4 since it is the fourth connexin of the alpha group that was identified1,2. Connexins do not function as single proteins, six connexins assemble into connexons (hemi-channels), and two connexons from neighboring cells dock in the extracellular space to form a full gap junction channel. Connexins are responsible for mediating direct communication between adjacent cells by the exchange of ions and small signaling molecules and cytosolic factors1,3. Their structure consists of four transmembrane helices, two extracellular loops, a cytoplasmic loop, a cytoplasmic NH2- and COOH-termini1,2.Connexin-37 is encoded by the GJA4 gene and is expressed in vascular endothelial cells. The protein is responsible for regulating and controlling the growth, proliferation and regeneration of the vascular endothelium by mediating the signal transduction between smooth muscle and endothelial cells. Cx37 knockout mice have a tendency for developing endarterium atheromatous plaques4. Also, a polymorphism in the gene that encodes for Cx37, is associated with increased risk for atherosclerosis and myocardial infarction1.
Alternative names: Connexin-37, CX37, Gap junction alpha4 protein, GJA4 -
基因ID
- 25655
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NCBI登录号
- NM_002060
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UniProt
- Q03190
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途径
- Cell-Cell Junction Organization
抗原
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