GABRD 抗体 (Extracellular, N-Term)
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Quick Overview for GABRD 抗体 (Extracellular, N-Term) (ABIN7043177)
抗原
See all GABRD 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 19-35, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to GABA(A) δ Receptor
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交叉反应
- 小鼠, 大鼠
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预测反应
- Mouse - identical, human - 14,17 amino acid residues identical
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产品特性
- Anti-GABA(A) δ Receptor (extracellular) Antibody (ABIN7043177, ABIN7044311 and ABIN7044312) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize GABA(A) δ from human, rat, and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)HHGARAMNDIGDYVGSN, corresponding to amino acid residues 19-35 of rat GABA(A) delta receptor
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亚型
- IgG
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anti-GABA A Receptor delta (GABRD) (N-Term) antibody
GABRD 适用: 人, 小鼠, 犬, Cow, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-GABA A Receptor delta (GABRD) (AA 331-358) antibodyGABRD 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB23938 unconjugated
anti-GABA A Receptor delta (GABRD) (N-Term) antibodyGABRD 适用: 人, 大鼠, 小鼠, 犬, Cow, 小鸡 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-GABA A Receptor delta (GABRD) (N-Term) antibodyGABRD 适用: 人, 大鼠, 小鼠, 犬, Cow, 兔, Bat, 豚鼠, Hamster, 马 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-GABA A Receptor delta (GABRD) (Internal Region) antibodyGABRD 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-GABA A Receptor delta (GABRD) (AA 331-358) antibodyGABRD 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-GABA A Receptor delta (GABRD) (N-Term) antibodyGABRD 适用: 人, 大鼠, 小鼠, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-GABA A Receptor delta (GABRD) (N-Term) antibodyGABRD 适用: 人, 大鼠, 小鼠, 犬, Cow, 兔, Bat, 豚鼠, Hamster, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-GABA A Receptor delta (GABRD) (AA 330-430) antibodyGABRD 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: 2.5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Cited Application: ICC
Negative Control: (ABIN7235461)
Blocking Peptide: (ABIN7235461)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- GABRD (GABA A Receptor delta (GABRD))
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别名
- GABRD
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背景
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Synonyms: GABRD, Gamma-aminobutyric acid receptor subunit delta, GABA(A) receptor subunit delta
Description: GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. Its production, release, reuptake, and metabolism all occur in the nervous system1.The GABA transmitter interacts with two major types of receptors: ionotropic GABAA receptors (GABAAR) and metabotropic receptors (GABABR). GABAARs belong to the ligand-gated ion channel superfamily2. GABA inhibits the activity of signal-receiving neurons by interacting with the GABAA receptor on these cells3. Binding of GABA to its GABAA receptor results in conformational changes that open a Cl- channel, producing an increase in membrane conductance that results in inhibition of neural activity2.GABAARs are heteropentamers, in which all five subunits contribute to the pore formation. To date, eight subunit isoforms have been cloned: α, β, γ, δ, ε, π, θ, and ?1. Six α subunit isoforms have been found to exist in mammals (α1-α6). In most cases, native GABAA receptors consist of 2α, 2β, and 1γ subunits. The α subunit is the most common and is expressed ubiquitously. It determines the affinity of GABAARs for allosteric ligands.Each subtype has a unique regional expression in the brain, and individual neurons often express multiple subtypes4. For example, the α4 subunit is detected in the hippocampus, cortex, olfactory bulb and in the basal forebrain5.
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基因ID
- 29689
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NCBI登录号
- NM_000815
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UniProt
- P18506
抗原
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