GPR52 抗体 (AA 239-253)
Quick Overview for GPR52 抗体 (AA 239-253) (ABIN7043161)
抗原
See all GPR52 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 239-253
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原理
- A Rabbit Polyclonal Antibody to GPR52
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特异性
- 3rd intracellular loop
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- human - 13,Rat - 14,15 amino acid residues identical
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产品特性
- Anti-GPR52 Antibody (ABIN7043161, ABIN7044453 and ABIN7044454) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry. It has been designed to recognize GPR52 from human, mouse, and rat samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)DRRARFPSHEVEASR, corresponding to amino acid residues 239 - 253 of mouse GPR52
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亚型
- IgG
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anti-G Protein-Coupled Receptor 52 (GPR52) (AA 218-245), (C-Term) antibody
GPR52 适用: 人 WB 宿主: 兔 Polyclonal RB40646 unconjugated
anti-G Protein-Coupled Receptor 52 (GPR52) (C-Term) antibodyGPR52 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 52 (GPR52) (AA 1-30) antibodyGPR52 适用: 人, 小鼠 WB, IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 52 (GPR52) (Cytoplasmic Domain) antibodyGPR52 适用: 人, 兔 IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 52 (GPR52) (AA 151-250) antibodyGPR52 适用: 人 WB, ELISA, IHC (p), ICC, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 52 (GPR52) (AA 225-265) antibodyGPR52 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 52 (GPR52) antibodyGPR52 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 52 (GPR52) (AA 311-360) antibodyGPR52 适用: 人 WB, ELISA, IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 52 (GPR52) (AA 165-202) antibodyGPR52 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:300
Application Dilutions Western blot wb: 1:200
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说明
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Negative Control: (ABIN7235423)
Blocking Peptide: (ABIN7235423)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- GPR52 (G Protein-Coupled Receptor 52 (GPR52))
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别名
- GPR52
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背景
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G-Protein Coupled Receptor 52,G-Protein Coupled Receptor 52 (GPR52) is a conserved class-A orphan receptor, a member of the of the GPCR superfamily. The native ligand for GPR52 is unknown but the receptor has a high level of basal activity not related to ligand binding. Structure analysis shows that GPR52 extracellular loop 2 occupies the orthosteric binding pocket and operates as a built-in agonist, enabling an intrinsically high level of basal activity. The receptor also features a side pocket for ligand binding3.Tissue distribution analysis of human, mouse, and rat indicates that GPR52 is expressed exclusively in the brain, especially in striatum. In the human brain, GPR52 expression profile overlaps with the distribution of D1 and D2 dopamine receptors which are associated with its function1.GPR52 inhibits dopamine D2 receptor signaling and activates dopamine D1/NMDA receptors via intracellular cAMP accumulation2.GPR52 is involved in the manifestation of schizophrenia, Huntington's disease, cognitive impairment and hyperactivity and several other psychiatric disorders and hence it represents a promising therapeutic target. Agonists may potentially act as a novel class of antipsychotics1,2.
Alternative names: G-Protein Coupled Receptor 52, GPR52 -
基因ID
- 620246
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NCBI登录号
- NM_005684
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UniProt
- P0C5J4
抗原
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