GPR39 抗体 (3rd Extracellular Loop)
Our Local Distributor
北京 101111
Quick Overview for GPR39 抗体 (3rd Extracellular Loop) (ABIN7043159)
抗原
See all GPR39 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- 3rd Extracellular Loop, AA 309-320
-
原理
- A Rabbit Polyclonal Antibody to GPR39
-
交叉反应
- 人, 小鼠, 大鼠
-
预测反应
- rat - 9,Human - 11,12 amino acid residues identical
-
产品特性
- Anti-GPR39 (extracellular) Antibody (ABIN7043159, ABIN7044429 and ABIN7044430) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot analysis. The antibody recognizes an extracellular epitope and can potentially be used for detecting the protein in living cells. It has been designed to recognize GPR39 from human, mouse, and rat samples.
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
- (C)KPKHDWTRTYFR, corresponding to amino acid residues 309-320 of mouse GPR39
-
亚型
- IgG
-
-
anti-G Protein-Coupled Receptor 39 (GPR39) (Extracellular Domain) antibody
GPR39 适用: 人, 小鼠, 大鼠, 马, 兔 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 39 (GPR39) (C-Term) antibodyGPR39 适用: 人 ELISA, WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 39 (GPR39) (AA 345-453) antibodyGPR39 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 39 (GPR39) (AA 379-407), (C-Term) antibodyGPR39 适用: 人 WB 宿主: 兔 Polyclonal RB40394 unconjugated
anti-G Protein-Coupled Receptor 39 (GPR39) (AA 377-391) antibodyVerified GPR39 适用: 人 ELISA, WB 宿主: 山羊 Polyclonal unconjugated
-
-
应用备注
-
WB: 1:200
FC: 2.5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
-
说明
-
Negative Control: (ABIN7235412)
Blocking Peptide: (ABIN7235412)
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
-
浓度
- 0.8 mg/mL
-
缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
-
-
- GPR39 (G Protein-Coupled Receptor 39 (GPR39))
-
别名
- GPR39
-
背景
-
Synonyms: G-protein coupled receptor 39, Zinc receptor GPR39
Description: GPR39 (G-protein coupled receptor 39) is member of the rhodopsin-like family of 7-transmembrane containing GPCRs and is closely related to the ghrelin/neurotensin receptor subfamily.The human GPR39 gene encodes the full-length receptor (GPR39-1a). GPR39 is expressed in various tissues including adipose tissue, heart and thyroid but is most abundant in the pancreas, GI tract, liver and kidney. The GPR39 receptor is comprised of an extracellular N-terminus, seven membrane spanning loops, and an intracellular C-terminus. It also contains four cysteine residues in its extracellular domains. These have been shown to form two disulfide bridges which are conserved within all vertebrate GPR39 sequences with the exception that the first bridge is absent from the fish receptors.Although GPR39 has a high degree of constitutive activity mediated through Gαq and Gα12/13 pathways, it has been discovered recently that Zn2+ serves as a ligand capable of activating the receptor. Following Zinc activation, both pathways are significantly enhanced and signaling occurs through the Gαs pathway as well.GPR39 has been implicated in several pathologies: Disruption of the GPR39 gene is associated with impaired insulin secretion. GPR39 knockout mice exhibit decreased insulin levels and lower levels of insulin promoting factor-1 and HNF-1α in pancreatic islets. GPR39 knockout mice also exhibit lower levels of CREB and BDNF proteins that are important in neuronal plasticity and antidepressant response thus leading to depressive-like behaviors in animals.
-
基因ID
- 71111
-
NCBI登录号
- NM_001508
-
UniProt
- Q5U431
-
途径
- Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Feeding Behaviour
抗原
-
