G Protein-Coupled Receptor 119 抗体 (2nd Cytoplasmic Loop)
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Quick Overview for G Protein-Coupled Receptor 119 抗体 (2nd Cytoplasmic Loop) (ABIN7043147)
抗原
See all G Protein-Coupled Receptor 119 (GPR119) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- 2nd Cytoplasmic Loop, AA 186-200
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原理
- A Rabbit Polyclonal Antibody to Glucose-Dependent Insulinotropic Receptor (GPR119)
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交叉反应
- 小鼠, 大鼠
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预测反应
- human - 13,15 amino acid residues identical,Mouse - 14
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产品特性
- Anti-GPR119 Antibody is directed against an epitope of the rat Glucose-dependent insulinotropic receptor. Anti-GPR119 Antibody (ABIN7043147, ABIN7044419 and ABIN7044420) can be used in western blot analysis. It has been designed to recognize GPR119 from rat, mouse and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- CDMLK IASVHSQHIR, corresponding to amino acid residues 186-200 of rat GPR119
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亚型
- IgG
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anti-G Protein-Coupled Receptor 119 (GPR119) (Cytoplasmic Domain) antibody
GPR119 适用: 人, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 119 (GPR119) antibodyGPR119 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 119 (GPR119) (Internal Region) antibodyGPR119 适用: 人, 小鼠 WB, ELISA, IF, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 119 (GPR119) (Cytoplasmic Domain) antibodyGPR119 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 119 (GPR119) (Internal Region) antibodyGPR119 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 119 (GPR119) (Center) antibodyGPR119 适用: 人, 猴 WB, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 119 (GPR119) antibodyGPR119 适用: 人, 小鼠, 大鼠, 犬 ELISA, IF, BP 宿主: 兔 Chimeric Gipg013 unconjugated Recombinant Antibody
anti-G Protein-Coupled Receptor 119 (GPR119) (C-Term) antibodyVerified GPR119 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 119 (GPR119) (AA 186-235) antibodyGPR119 适用: 人 WB, ELISA, IF, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 119 (GPR119) (AA 186-235) antibodyGPR119 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:400
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235360)
Blocking Peptide: (ABIN7235360)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- G Protein-Coupled Receptor 119 (GPR119)
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别名
- GPR119
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背景
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Synonyms: Glucose-dependent insulinotropic receptor, GPCR2
Description: Glucose-dependent insulinotropic receptor (GPR119) is a rhodopsin-type member of the G protein-coupled receptor (GPCRs) superfamily. Like all members, it has seven transmembrane spanning domains, an extracellular N-terminus and intracellular C-terminus. Activation of the receptor leads to a rise in intracellular cAMP - suggesting a stimulation of adenylate cyclase, possibly by Gαs coupling. It is expressed mostly in enteroendocrine cells of the gastrointenstinal tract and b-cells of the pancreas. It was stipulated that GPR119 is a close relative to the cannabinoid receptors1,2.Phospholipids and fatty acid amides are endogenous ligands for GPR119. Notably, oleoethanolamide (OEA) seems to be an important agonist. Stimulation of GPR119 by its agonists causes b-cells to release insulin and enteroendocrine cells to release glucagon-like peptide-1 (GLP-1), this attribute makes GPR119 a strong therapeutic candidate for type-2 diabetes and obesity3,4. Furthermore, its ability to release GLP-1 upon stimulation by dietary fat has gained it the title "fat sensor"5 .
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基因ID
- 302813
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NCBI登录号
- NM_178471
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UniProt
- Q7TQN8
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途径
- Hormone Transport, Peptide Hormone Metabolism
抗原
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