G Protein-Coupled Receptor 119 抗体 (AA 186-200)
Quick Overview for G Protein-Coupled Receptor 119 抗体 (AA 186-200) (ABIN7043147)
抗原
See all G Protein-Coupled Receptor 119 (GPR119) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 186-200
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原理
- A Rabbit Polyclonal Antibody to Glucose-Dependent Insulinotropic Receptor (GPR119)
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特异性
- 2nd intracellular loop
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交叉反应
- 小鼠, 大鼠
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预测反应
- human - 13,15 amino acid residues identical,Mouse - 14
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产品特性
- Anti-GPR119 Antibody is directed against an epitope of the rat Glucose-dependent insulinotropic receptor. Anti-GPR119 Antibody (ABIN7043147, ABIN7044419 and ABIN7044420) can be used in western blot analysis. It has been designed to recognize GPR119 from rat, mouse and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: CDMLK IASVHSQHIR, corresponding to amino acid residues 186-200 of rat GPR119
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亚型
- IgG
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anti-G Protein-Coupled Receptor 119 (GPR119) (Cytoplasmic Domain) antibody
GPR119 适用: 人, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 119 (GPR119) (Internal Region) antibodyGPR119 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 119 (GPR119) antibodyGPR119 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 119 (GPR119) (Cytoplasmic Domain) antibodyGPR119 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 119 (GPR119) (Internal Region) antibodyGPR119 适用: 人, 小鼠 WB, ELISA, IF, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 119 (GPR119) (Center) antibodyGPR119 适用: 人, 猴 WB, IF, IHC, IC 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 119 (GPR119) (AA 186-235) antibodyGPR119 适用: 人 WB, ELISA, IF, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 119 (GPR119) (C-Term) antibodyVerified GPR119 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 119 (GPR119) antibodyGPR119 适用: 人, 小鼠, 大鼠, 犬 ELISA, IF, BP 宿主: 兔 Chimeric Gipg013 unconjugated Recombinant Antibody
anti-G Protein-Coupled Receptor 119 (GPR119) (AA 186-235) antibodyGPR119 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:400
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说明
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Negative Control: (ABIN7235360)
Blocking Peptide: (ABIN7235360)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- G Protein-Coupled Receptor 119 (GPR119)
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别名
- GPR119
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背景
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Glucose-dependent insulinotropic receptor, GPCR2,Glucose-dependent insulinotropic receptor (GPR119) is a rhodopsin-type member of the G protein-coupled receptor (GPCRs) superfamily. Like all members, it has seven transmembrane spanning domains, an extracellular N-terminus and intracellular C-terminus. Activation of the receptor leads to a rise in intracellular cAMP - suggesting a stimulation of adenylate cyclase, possibly by Gαs coupling. It is expressed mostly in enteroendocrine cells of the gastrointenstinal tract and b-cells of the pancreas. It was stipulated that GPR119 is a close relative to the cannabinoid receptors1,2.Phospholipids and fatty acid amides are endogenous ligands for GPR119. Notably, oleoethanolamide (OEA) seems to be an important agonist. Stimulation of GPR119 by its agonists causes b-cells to release insulin and enteroendocrine cells to release glucagon-like peptide-1 (GLP-1), this attribute makes GPR119 a strong therapeutic candidate for type-2 diabetes and obesity3,4. Furthermore, its ability to release GLP-1 upon stimulation by dietary fat has gained it the title "fat sensor"5 .
Alternative names: GPR119, Glucose-dependent insulinotropic receptor, GPCR2 -
基因ID
- 302813
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NCBI登录号
- NM_178471
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UniProt
- Q7TQN8
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途径
- Hormone Transport, Peptide Hormone Metabolism
抗原
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