PIEZO2 抗体 (AA 1092-1104)
Quick Overview for PIEZO2 抗体 (AA 1092-1104) (ABIN7043133)
抗原
See all PIEZO2 (FAM38B) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 1092-1104
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原理
- A Rabbit Polyclonal Antibody to Piezo2
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特异性
- Located in an internal region of human Piezo2 (the exact topology of Piezo2 remains to be defined).
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,rat - 12,13 amino acid residues identical
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产品特性
- Anti-Piezo2 Antibody (ABIN7043133, ABIN7044990 and ABIN7044991) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot analysis. It has been designed to recognize Piezo2 from human, rat, and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)RTIFHDITRLHLD, corresponding to amino acid residues 1092 - 1104 of human Piezo2
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亚型
- IgG
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anti-Family with Sequence Similarity 38, Member B (FAM38B) antibody
FAM38B 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Family with Sequence Similarity 38, Member B (FAM38B) (AA 2570-2619) antibodyFAM38B 适用: 人, 小鼠, 大鼠, Cow, 兔, 豚鼠, 犬, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Family with Sequence Similarity 38, Member B (FAM38B) (Middle Region) antibodyFAM38B 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200
Application Dilutions Western blot wb: 1:200
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说明
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Cited Application: IP|IHC|ICC|Whole Tissue Staining
Negative Control: (ABIN7235322)
Blocking Peptide: (ABIN7235322)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- PIEZO2 (FAM38B) (Family with Sequence Similarity 38, Member B (FAM38B))
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别名
- PIEZO2
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背景
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Piezo-Type Mechanosensitive Ion Channel Component 2, Protein FAM38B,Piezo-type mechanosensitive ion channel component 2 (Piezo2) is a homotrimeric ion channel. Piezo2 depicts rapidly adapting mechanically activated (MA) currents in somatosensory neurons.Piezo1 and Piezo2 comprise the Piezo protein family. These are large transmembrane proteins are conserved among various species, and all have between 24 and 36 predicted transmembrane domains. Both channels open in response to mechanical stimuli, allowing positively charged ions, including calcium, to flow into the cell1.Piezo2 protein contains over 2,800 residues, it forms a three-bladed, propeller like trimer that comprises 114 transmembrane helices (38 per protomer). Transmembrane helices 1-36 (TM1-36) are folded into nine tandem units of four transmembrane helices each to form the unusual non-planar blades2.Piezo2 has an essential role in sensing gentle touch, tactile pain, airway stretch and lung inflation. It also serves as a baroreceptor for sensing blood pressure and regulating heart rate. Mutations in human Piezo2 are associated with distal arthrogryposis, a disorder characterized by joint deformities (contractures) that restrict movement in the hands and feet3,4.
Alternative names: Piezo-Type Mechanosensitive Ion Channel Component 2, Protein FAM38B -
基因ID
- 63895
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NCBI登录号
- NM_022068
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UniProt
- Q9H5I5
抗原
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