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PIEZO2 抗体 (AA 1092-1104)

KO Validated FAM38B 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7043133
发货至: 中国
  • 抗原 See all PIEZO2 (FAM38B) 抗体
    PIEZO2 (FAM38B) (Family with Sequence Similarity 38, Member B (FAM38B))
    抗原表位
    • 8
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1092-1104
    适用
    • 18
    • 14
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    宿主
    • 26
    克隆类型
    • 26
    多克隆
    标记
    • 13
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PIEZO2 antibody is un-conjugated
    应用范围
    • 10
    • 10
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    原理
    A Rabbit Polyclonal Antibody to Piezo2
    特异性
    Located in an internal region of human Piezo2 (the exact topology of Piezo2 remains to be defined).
    交叉反应
    人, 小鼠, 大鼠
    预测反应
    Mouse,rat - 12,13 amino acid residues identical
    产品特性
    Anti-Piezo2 Antibody (ABIN7043133, ABIN7044990 and ABIN7044991) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot analysis. It has been designed to recognize Piezo2 from human, rat, and mouse samples.
    纯化方法
    Affinity purified on immobilized antigen.
    质量等级
    KO Validated
    免疫原

    Immunogen: Synthetic peptide

    Immunogen Sequence: (C)RTIFHDITRLHLD, corresponding to amino acid residues 1092 - 1104 of human Piezo2

    亚型
    IgG
  • 应用备注

    Antigen preadsorption control: 1 μg peptide per 1 μg antibody

    Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200

    Application Dilutions Western blot wb: 1:200

    说明

    Cited Application: IP|IHC|ICC|Whole Tissue Staining

    Negative Control: (ABIN7235322)

    Blocking Peptide: (ABIN7235322)

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
    浓度
    1 mg/mL
    缓冲液
    PBS pH 7.4
    储存条件
    4 °C,-20 °C
    储存方法

    Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

    Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

  • 抗原
    PIEZO2 (FAM38B) (Family with Sequence Similarity 38, Member B (FAM38B))
    别名
    PIEZO2 (FAM38B 产品)
    背景
    Piezo-Type Mechanosensitive Ion Channel Component 2, Protein FAM38B,Piezo-type mechanosensitive ion channel component 2 (Piezo2) is a homotrimeric ion channel. Piezo2 depicts rapidly adapting mechanically activated (MA) currents in somatosensory neurons.Piezo1 and Piezo2 comprise the Piezo protein family. These are large transmembrane proteins are conserved among various species, and all have between 24 and 36 predicted transmembrane domains. Both channels open in response to mechanical stimuli, allowing positively charged ions, including calcium, to flow into the cell1.Piezo2 protein contains over 2,800 residues, it forms a three-bladed, propeller like trimer that comprises 114 transmembrane helices (38 per protomer). Transmembrane helices 1-36 (TM1-36) are folded into nine tandem units of four transmembrane helices each to form the unusual non-planar blades2.Piezo2 has an essential role in sensing gentle touch, tactile pain, airway stretch and lung inflation. It also serves as a baroreceptor for sensing blood pressure and regulating heart rate. Mutations in human Piezo2 are associated with distal arthrogryposis, a disorder characterized by joint deformities (contractures) that restrict movement in the hands and feet3,4.

    Alternative names: Piezo-Type Mechanosensitive Ion Channel Component 2, Protein FAM38B
    基因ID
    63895
    NCBI登录号
    NM_022068
    UniProt
    Q9H5I5
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