Dopamine Receptor d1 抗体 (C-Term, Intracellular)
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Quick Overview for Dopamine Receptor d1 抗体 (C-Term, Intracellular) (ABIN7043105)
抗原
See all Dopamine Receptor d1 (DRD1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 372-385, C-Term, Intracellular
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原理
- A Rabbit Polyclonal Antibody to D1 Dopamine Receptor
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交叉反应
- 小鼠, 大鼠
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预测反应
- Mouse,dog,pig - identical, human - 13,14 amino acid residues identical
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产品特性
- Anti-D1 Dopamine Receptor Antibody (ABIN7043105, ABIN7044227 and ABIN7044228) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize DRD1 from rat, mouse, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- SSHHEPRGSISKDC, corresponding to amino acid residues 372-385 of rat DRD1
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亚型
- IgG
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anti-Dopamine Receptor D1 (DRD1) (AA 338-446) antibody
DRD1 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D1 (DRD1) (AA 101-200) antibodyDRD1 适用: 人, 大鼠, 小鼠 WB, ELISA, ICC, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D1 (DRD1) (AA 11-100) antibodyDRD1 适用: 人, 大鼠 WB, ELISA, ICC, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D1 (DRD1) (N-Term) antibodyDRD1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D1 (DRD1) (AA 338-446) antibodyDRD1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D1 (DRD1) (C-Term) antibodyDRD1 适用: 人 WB, ICC, IF, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D1 (DRD1) (AA 338-446) antibodyDRD1 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D1 (DRD1) (C-Term) antibodyDRD1 适用: 人, 猴, 兔 IHC, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D1 (DRD1) (C-Term) antibodyDRD1 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Dopamine Receptor D1 (DRD1) (Extracellular Domain) antibodyDRD1 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:100
IP: The optimal concentration should be determined by the user
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说明
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Cited Application: IHC
Negative Control: (ABIN7235235)
Blocking Peptide: (ABIN7235235)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Dopamine Receptor d1 (DRD1) (Dopamine Receptor D1 (DRD1))
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别名
- DRD1
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背景
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Synonyms: DRD1, D(1A) dopamine receptor
Description: The D1 dopamine receptor (D1 receptor, DRD1) is one of five receptors that mediate the effects of the catecholamine neurotransmitter dopamine. Dopamine regulates a variety of functions including locomotor activity, emotion, positive reinforcement, food intake, and hormone secretion. The dopaminergic system has been extensively studied in the last thirty years mainly because its dysregulation has been linked to several neurological and neuropsychiatric diseases including Parkinson's disease and Schizophrenia1.All five dopamine receptors belong to the 7-transmembrane domain, G-protein coupled receptor (GPCR) superfamily.Historically, the five receptors have been divided into two subfamilies based on pharmacological and structural considerations: the D1-like subfamily (that includes the D1 and D5 subtypes) and the D2-like subfamily (that includes the D2-, D3- and D4 subtypes)1.The D1-like receptors are coupled to Gs-type G proteins and enhance adenylate cyclase activity while the D2-like receptors are coupled to Gi-type G proteins and inhibit adenylate cyclase activity1.The D1 receptor is widely distributed throughout the brain with the highest expression in the cerebral cortex and striatum. In the periphery the D1 receptor has been detected in the adrenal cortex, kidney and heart.Functionally, the D1 receptor has been implicated in the regulation of both locomotor and cognitive functions including the maintaining of spontaneous motor behaviors, the control of working memory and cognition as well as the regulation of craving and reward pathways.In addition, the D1 receptor plays an important role in the pathogenesis of hypertension by regulating epithelial Na+ transport and by interacting with vasoactive hormones/humoral factors, such as aldosterone and angiotensin1,2.
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基因ID
- 24316
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NCBI登录号
- NM_000794
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UniProt
- P18901
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途径
- cAMP Metabolic Process, Inositol Metabolic Process, Protein targeting to Nucleus, Feeding Behaviour, Smooth Muscle Cell Migration, Regulation of long-term Neuronal Synaptic Plasticity
抗原
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