DLG1 抗体 (L27 Domain, N-Term)
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Quick Overview for DLG1 抗体 (L27 Domain, N-Term) (ABIN7043101)
抗原
See all DLG1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 17-31, L27 Domain, N-Term
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原理
- A Rabbit Polyclonal Antibody to SAP-97
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rat,mouse - identical
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产品特性
- Anti-/DLG1 Antibody is directed against an epitope of human . Anti-/DLG1 Antibody (ABIN7043101, ABIN7045150 and ABIN7045151) can be used in western blot analysis. It has been designed to recognize from rat, mouse and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)EYRSKLSQTEDRQLR, corresponding to amino acid residues 17-31 of human SAP-97
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亚型
- IgG
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anti-Discs, Large Homolog 1 (DLG1) antibody
KD Validated DLG1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB3595 unconjugated Recombinant Antibody
anti-Discs, Large Homolog 1 (DLG1) (AA 1-90) antibodyDLG1 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 1D8 unconjugated
anti-Discs, Large Homolog 1 (DLG1) (Internal Region) antibodyDLG1 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Discs, Large Homolog 1 (DLG1) (AA 662-773) antibodyDLG1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Discs, Large Homolog 1 (DLG1) (AA 1-190) antibodyDLG1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Discs, Large Homolog 1 (DLG1) (AA 643-673) antibodyDLG1 适用: 人 WB 宿主: 兔 Polyclonal RB53955 unconjugated
anti-Discs, Large Homolog 1 (DLG1) (Internal Region) antibodyVerified DLG1 适用: 人 ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Discs, Large Homolog 1 (DLG1) (AA 1-90) antibodyDLG1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D8 unconjugated
anti-Discs, Large Homolog 1 (DLG1) (AA 1-90) antibodyDLG1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1B12 unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235220)
Blocking Peptide: (ABIN7235220)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- DLG1 (Discs, Large Homolog 1 (DLG1))
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别名
- DLG1
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背景
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Synonyms: Synapse-associated protein 97, Discs large homolog 1
Description: SAP-97 belongs to the MAGUK (membrane associated guanylate kinase) homologs along with PSD-95, PSD-93 and SAP102.Like other members, SAP-97 has three PDZ domains, one SH3 domain and an inactive GUK domain. Alternative splicing of SAP-97 gives to a number of different isoforms thereby complicating the understanding of its roles1.In the post-synaptic cell, SAP-97 is the only MAGUK to directly interact with the GluA1 AMPA receptor2. SAP-97 also directly interacts with NMDA receptors through the PDZ domain3,4.SAP-97 was shown to interact with KV1.45 and with KV4.2 where it directs the channel to spines in hippocampal neurons6. It can also interact with the channel in the heart7.Interactions with Kir channels have also been observed8,9.Thus, SAP-97 serves as a regulator of neuronal excitability and synaptic function. Roles for the protein in schizophrenia, Alzheimer's and Parkinson's disease and epilepsy have been found1.
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基因ID
- 1739
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NCBI登录号
- NM_004087
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UniProt
- Q12959
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途径
- Regulation of Actin Filament Polymerization, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response
抗原
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