DPYSL2 抗体 (Intracellular)
Our Local Distributor
北京 101111
Quick Overview for DPYSL2 抗体 (Intracellular) (ABIN7043097)
抗原
See all DPYSL2 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 504-517, Intracellular
-
原理
- A Rabbit Polyclonal Antibody to CRMP-2
-
交叉反应
- 人, 小鼠, 大鼠
-
预测反应
- Mouse,human - identical
-
产品特性
- Anti-CRMP2 Antibody (ABIN7043097, ABIN7044542 and ABIN7044543) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot analysis. It has been designed to recognize from rat, mouse, and human samples.
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
- CEVSVTPKTVTPAS, corresponding to amino acid residues 504-517 of rat CRMP2
-
亚型
- IgG
-
-
anti-Dihydropyrimidinase-Like 2 (DPYSL2) (C-Term) antibody
DPYSL2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Dihydropyrimidinase-Like 2 (DPYSL2) (AA 470-571) antibodyDPYSL2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1F11 unconjugated
anti-Dihydropyrimidinase-Like 2 (DPYSL2) (AA 1-572) antibodyDPYSL2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Dihydropyrimidinase-Like 2 (DPYSL2) antibodyDPYSL2 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Dihydropyrimidinase-Like 2 (DPYSL2) (AA 400-500) antibodyKO Validated DPYSL2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Dihydropyrimidinase-Like 2 (DPYSL2) (C-Term) antibodyDPYSL2 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Dihydropyrimidinase-Like 2 (DPYSL2) (AA 463-492) antibodyDPYSL2 适用: 人, 小鼠 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 33CT11-40-3 unconjugated
anti-Dihydropyrimidinase-Like 2 (DPYSL2) (AA 480-529) antibodyDPYSL2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Dihydropyrimidinase-Like 2 (DPYSL2) (Thr509) antibodyDPYSL2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Dihydropyrimidinase-Like 2 (DPYSL2) antibodyKD Validated DPYSL2 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB2985 unconjugated Recombinant Antibody
-
-
应用备注
-
WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:300
IP: The optimal concentration should be determined by the user
-
说明
-
Negative Control: (ABIN7235204)
Blocking Peptide: (ABIN7235204)
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
-
浓度
- 0.8 mg/mL
-
缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
-
-
- DPYSL2 (Dihydropyrimidinase-Like 2 (DPYSL2))
-
别名
- DPYSL2
-
背景
-
Synonyms: CRMP-2, Collapsin response mediator protein 2, Dihydropyrimidinase-related protein 2, DHPRP2, DRP-2, Dpysl2, Turned on after division 64 kDa protein, TOAD-64, Ulip2, Unc-33-like phosphoprotein 2
Description: Collapsin response mediator protein 2 (CRMP-2, DRP-2), is a kinesin-binding protein and a member of the CRMP family, a novel family of microtubule-associated proteins (MAPs). This family consists of 5 highly conserved phosphorylated proteins: CRMP1-CRMP5. CRMP-2 was originally identified in the regulation of microtubule dimerization. CRMP-2 is the first member of the CRMP family identified in primary neuronal cells1,2.Physiological functions of CRMP-2 protein include regulation of cell surface receptor endocytosis, kinesin-dependent axonal transport, growth cone collapse, polarity and differentiation of developing neurons and neurite outgrowth and the regulation of microtubule dynamics2.Studies suggest that CRMP-2 can modulate neuronal viability through the PI3K/mTOR/S6K pathway. In addition, CRMP-2 expression has been detected in non-neuronal cells such as leukocytes, fibroblasts and neuroblastoma1.Phosphorylation of CRMP-2 on specific Thr and Ser residues inactivates its activity, leading to inhibition of axonal growth and neuronal polarity. Knockdown of CRMP-2 shortens the total dendritic length and decreases dendritic branching3.
-
基因ID
- 25416
-
NCBI登录号
- NM_001386
-
UniProt
- P47942
-
途径
- Regulation of Cell Size
抗原
-
