CasLTR2 抗体 (Extracellular)
Quick Overview for CasLTR2 抗体 (Extracellular) (ABIN7043095)
抗原
See all CasLTR2 (CYSLTR2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 270-284, Extracellular
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原理
- A Rabbit Polyclonal Antibody to Human CysLTR2
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特异性
- 3rd extracellular loop
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交叉反应 （详细）
- Not recommended for use with rat and mouse samples.
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预测反应
- Human only
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产品特性
- Anti-Human CysLTR2 (extracellular) Antibody (ABIN7043095 and ABIN7044560) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot and indirect live cell flow cytometry applications. It has been designed to recognize CysLTR2 from human samples only.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)HLTTWKVGL(S)KDRLH, corresponding to amino acid residues 270-284 of human CysLTR2
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亚型
- IgG
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anti-Cysteinyl Leukotriene Receptor 2 (CYSLTR2) (Extracellular Domain) antibody
CYSLTR2 适用: 人, 马 ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cysteinyl Leukotriene Receptor 2 (CYSLTR2) (N-Term) antibodyCYSLTR2 适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cysteinyl Leukotriene Receptor 2 (CYSLTR2) (C-Term) antibodyCYSLTR2 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Cysteinyl Leukotriene Receptor 2 (CYSLTR2) antibodyCYSLTR2 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Cysteinyl Leukotriene Receptor 2 (CYSLTR2) (Internal Region) antibodyCYSLTR2 适用: 人 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- CasLTR2 (CYSLTR2) (Cysteinyl Leukotriene Receptor 2 (CYSLTR2))
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别名
- CYSLTR2
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背景
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CYSLT2, Cysteinyl leukotriene receptor 2, hGPCR21, G-protein coupled receptor HG57,LTC4, LTD4, and LTE4 are cysteinyl leukotrienes (cys-LTs) peptide conjugated lipids derived from arachidonic acid as a result of immune or inflammatory stimuli1-3.The above mentioned cys-LTs bind and activate two receptors belonging to the G-protein coupled receptor superfamily, CysLTR1 and CysLTR2 (also named cysLT1 and cysLT2 respectively). There is evidence though that other receptors are yet to be identified4. These two receptors couple to both pertussis toxin sensitive (Gi/o) and insensitive (Gq, which initiates Ca2+ influx) G-proteins for their signaling. The G-protein coupled to is probably determined by which ligand binds the receptor as all three cys-LTs can activate the two receptors albeit with different affinities5. In mouse, CysLTR1 and CysLTR2 are subject to alternative splicing. CysLTR1 receptor expresses greater affinity for LTD4 and binds equally to LTC4 and LTE4whereas CysLTR2 has greater and equal affinity towards LTC4 and LTD4 over LTE45.Human CysLTR1 is highly expressed in spleen, peripheral blood, leukocytes. It is less strongly expressed in lung, small intestine, pancreas and hardly or not expressed in liver, colon, kidney, skeletal muscle, testis heart and brain4. On the other hand, CysLTR2 is highly expressed in spleen and leukocytes. Its expression in the heart, brain, spinal cord and adrenal gland differs it from that of CysLTR14.Cys-LTs and their receptors are involved in respiratory diseases like asthma and other conditions such as cancer cardiovascular, gastrointestinal, skin and immune disorders1,6.
Alternative names: CysLTR2, CYSLT2, Cysteinyl leukotriene receptor 2, hGPCR21, G-protein coupled receptor HG57 -
基因ID
- 57105
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NCBI登录号
- NM_001308465
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UniProt
- Q9NS75
抗原
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