CysLTR1 抗体 (3rd Extracellular Loop) (FITC)
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Quick Overview for CysLTR1 抗体 (3rd Extracellular Loop) (FITC) (ABIN7043094)
抗原
See all CysLTR1 (CYSLTR1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- 3rd Extracellular Loop, AA 261-275
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原理
- A Rabbit Polyclonal Antibody to CysLTR1 Conjugated to the Fluorescent Dye FITC
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交叉反应
- 人, 小鼠
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预测反应
- mouse - 12,Human - 14, rat - 11,15 amino acid residues identical
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产品特性
- Anti-CysLTR1 (extracellular) Antibody (ABIN7043093, ABIN7044558 and ABIN7044559) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot and indirect live cell flow cytometry applications. It has been designed to recognize CysLTR1 from human, mouse, and rat samples. \nAnti-CysLTR1 (extracellular)-FITC Antibody (ABIN7043093, ABIN7044558 and ABIN7044559)-F) is directly conjugated to fluorescein isothiocyanate (FITC). The antibody can be used in immunofluorescent applications such as direct live cell flow cytometry.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)HNETKP(S)DSVLRMQK, corresponding to amino acid residues 261-275 of human CysLTR1
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亚型
- IgG
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anti-Cysteinyl Leukotriene Receptor 1 (CYSLTR1) (AA 298-337) antibody
CYSLTR1 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cysteinyl Leukotriene Receptor 1 (CYSLTR1) (Internal Region) antibodyCYSLTR1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cysteinyl Leukotriene Receptor 1 (CYSLTR1) (Extracellular Domain) antibodyCYSLTR1 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cysteinyl Leukotriene Receptor 1 (CYSLTR1) (Center) antibodyCYSLTR1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Cysteinyl Leukotriene Receptor 1 (CYSLTR1) (AA 248-337) antibodyCYSLTR1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Cysteinyl Leukotriene Receptor 1 (CYSLTR1) (AA 131-180) antibodyCYSLTR1 适用: 人 WB, ELISA, IF, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cysteinyl Leukotriene Receptor 1 (CYSLTR1) (AA 1-100) antibodyCYSLTR1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Cysteinyl Leukotriene Receptor 1 (CYSLTR1) (AA 199-248) antibodyCYSLTR1 适用: 人, 兔, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Cysteinyl Leukotriene Receptor 1 (CYSLTR1) antibodyCYSLTR1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Cysteinyl Leukotriene Receptor 1 (CYSLTR1) (Internal Region) antibodyCYSLTR1 适用: 人, 猴 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: The optimal concentration should be determined by the user
FC: 2.5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7582044)
Blocking Peptide: (ABIN7235196)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 50 μL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- CysLTR1 (CYSLTR1) (Cysteinyl Leukotriene Receptor 1 (CYSLTR1))
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别名
- CYSLTR1
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背景
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Synonyms: CYSLT1, Cysteinyl leukotriene receptor 1, Cysteinyl leukotriene D4 receptor, LTD4 receptor, G-protein coupled receptor HG55, HMTMF81
Description: LTC4, LTD4, and LTE4 are leukotrienes (cys-LTs) derived from arachidonic acid as a result of immune or inflammatory stimuli1-3.The above mentioned cys-LTs bind and activate two receptors belonging to the G-protein coupled receptor superfamily, CysLTR1 and CysLTR2 (also named cysLT1 and cysLT2 respectively). There is evidence though that other receptors are yet to be identified4. These two receptors couple to both pertussis toxin sensitive (Gi/o) and insensitive (Gq, which initiates Ca2+ influx) G-proteins for their signaling. The G-protein coupled to is probably determined by which ligand binds the receptor as all three cys-LTs can activate the two receptors albeit with different affinities5. In mouse, CysLTR1 and CysLTR2 are subject to alternative splicing. CysLTR1 receptor expresses greater affinity for LTD4 and binds equally to LTC4 and LTE4 whereas CysLTR2 has greater and equal affinity towards LTC4 and LTD4 over LTE45.Human CysLTR1 is highly expressed in spleen, peripheral blood, leukocytes. It is less strongly expressed in lung, small intestine, pancreas and hardly or not expressed in liver, colon, kidney, skeletal muscle, testis heart and brain4. On the other hand, CysLTR2 is highly expressed in spleen and leukocytes. Its expression in the heart, brain, spinal cord and adrenal gland differs it from that of CysLTR14.Cys-LTs and their receptors are involved in respiratory diseases like asthma and other conditions such as cancer cardiovascular, gastrointestinal, skin and immune disorders1,6.
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基因ID
- 10800
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NCBI登录号
- NM_001282186
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UniProt
- Q9Y271
抗原
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