CNGA2 抗体 (Intracellular)
Quick Overview for CNGA2 抗体 (Intracellular) (ABIN7043090)
抗原
See all CNGA2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 643-660, Intracellular
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原理
- A Rabbit Polyclonal Antibody to CNGA2 Channel
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特异性
- Intracellular, C-terminus
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- rabbit - 15,18 amino acid residues identical, human,bovine - 14,Mouse - identical
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产品特性
- Anti-CNGA2 Antibody is directed against an intracellular epitope of the rat CNGA2 channel. Anti-CNGA2 Antibody (ABIN7043090, ABIN7044955 and ABIN7044956) can be used in western blot, immunohistochemistry, and immunocytochemistry applications. It has been designed to recognize CNGA2 from human, rat, and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)KQNHEDDYLSDGINTPEP, corresponding to amino acid residues 643-660 of rat CNGA2.
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亚型
- IgG
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anti-Cyclic Nucleotide Gated Channel alpha 2 (CNGA2) (C-Term) antibody
CNGA2 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Cyclic Nucleotide Gated Channel alpha 2 (CNGA2) (Internal Region) antibodyCNGA2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Cyclic Nucleotide Gated Channel alpha 2 (CNGA2) (AA 155-250) antibodyCNGA2 适用: 人 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cyclic Nucleotide Gated Channel alpha 2 (CNGA2) antibodyCNGA2 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cyclic Nucleotide Gated Channel alpha 2 (CNGA2) (AA 190-218) antibodyCNGA2 适用: 人, 小鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cyclic Nucleotide Gated Channel alpha 2 (CNGA2) (AA 75-102), (N-Term) antibodyCNGA2 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB22211 unconjugated
anti-Cyclic Nucleotide Gated Channel alpha 2 (CNGA2) (AA 190-218), (N-Term) antibodyCNGA2 适用: 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100
Application Dilutions Western blot wb: 1:200
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说明
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Cited Application: IHC|ICC
Negative Control: (ABIN7235185)
Blocking Peptide: (ABIN7235185)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- CNGA2 (Cyclic Nucleotide Gated Channel alpha 2 (CNGA2))
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别名
- CNGA2
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背景
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Cyclic nucleotide-gated cation channel 2, CNG channel alpha-2, CNG2, CNCG2, Olfactory cyclic nucleotide gated channel 1, OCNC1,Cyclic nucleotides are important second messengers in many cellular functions such as visual transduction, and relaxation of smooth muscle cells. Cyclic nucleotides exert their cellular functions through three major classes of cellular receptors, one of them is the cyclic nucleotide-gated (CNG) channels.1 The CNG channels are non-selective cation channels facilitating the influx of Na+ and Ca2+ ions, following activation by intracellular cyclic nucleotides.2 In vertebrates, six members of the CNG channel family were identified and grouped according to sequence homology into two subtypes, CNGA and CNGB. To date, four types of the a subunits (CNGA1-4) and two b subunits (CNGB1, CNGB3) have been characterized.3 Native CNG channels are composed of a and b subunits in a tetrameric configuration. Each subunit contains 6 TM domains and intracellular cAMP or cGMP binding domains, but are also modulated by other factors including phosphorylation and calmodulin.4 In a heterologous expression system, only the a subunits are capable of forming functional homomeric channels. CNG ion channels are essential in visual and olfactory signal transduction.CNG channels were originally detected in rod and cone photoreceptors and olfactory receptor cells, where they mediate the transduction of external sensory stimuli into neuronal activity.5CNGA2 is predominantly expressed in olfactory neurons (the olfactory type receptor). However, electrophysiological and molecular data indicate that CNGA1, and especially CNGA2, are widely distributed and functionally active in many regions of the brain, including the hippocampus, cerebral cortex, cerebellum, and brainstem.6
Alternative names: CNGA2, Cyclic nucleotide-gated cation channel 2, CNG channel alpha-2, CNG2, CNCG2, Olfactory cyclic nucleotide gated channel 1, OCNC1 -
基因ID
- 108348053
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NCBI登录号
- NM_005140
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UniProt
- Q00195
抗原
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