CNTNAP2 抗体 (C-Term, Intracellular)
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Quick Overview for CNTNAP2 抗体 (C-Term, Intracellular) (ABIN7043084)
抗原
See all CNTNAP2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1315-1331, C-Term, Intracellular
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原理
- A Rabbit Polyclonal Antibody to Caspr2
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,rat - identical
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产品特性
- Anti-Caspr2 Antibody is directed against an epitope of human Caspr2. Anti-Caspr2 Antibody (ABIN7043084, ABIN7045145 and ABIN7045146) can be used in western blot and immunohistochemistry analysis. It has been designed to recognize Caspr2 from rat, mouse and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)DPNFTETIDESKKEWLI, corresponding to amino acid residues 1315-1331 of human Caspr2
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亚型
- IgG
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anti-Contactin Associated Protein-Like 2 (CNTNAP2) (AA 1-1331) antibody
CNTNAP2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Contactin Associated Protein-Like 2 (CNTNAP2) (AA 1079-1106) antibodyCNTNAP2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB22699 unconjugated
anti-Contactin Associated Protein-Like 2 (CNTNAP2) (AA 801-900) antibodyCNTNAP2 适用: 人, 大鼠 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Contactin Associated Protein-Like 2 (CNTNAP2) (AA 1-1331) antibodyCNTNAP2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Contactin Associated Protein-Like 2 (CNTNAP2) (Extracellular Domain) antibodyCNTNAP2 适用: 人 WB, IHC, IP, FM 宿主: 小鼠 Monoclonal S67-25 unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:200
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7566011)
Blocking Peptide: (ABIN7566011)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- CNTNAP2 (Contactin Associated Protein-Like 2 (CNTNAP2))
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别名
- CNTNAP2
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背景
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Synonyms: Contactin-associated protein-like 2, CNTNAP2
Description: Contactin-associated protein 2 (Caspr2) is a member of the neurexin superfamily, a group of transmembrane proteins that mediate cell-to-cell interactions in the nervous system1,2.Neurexins are adhesion molecules expressed mainly at presynaptic locations that form trans-synaptic cell-to-cell adhesion complexes via binding to their postsynaptic partners, the neuroligins2.Caspr2, like other neurexin proteins, is a type I membrane protein that contains epidermal growth factor repeats, laminin G domains, an F5/8 type C domain, and fibrinogen-like domains in its extracellular domain1,2.Caspr2 is localized at the juxtaparanodes of myelinated axons, a specialized region that mediates interactions between neurons and glia during nervous system development1.The juxtaparanodal region is highly enriched with heteromultimers of the K+ channels KV1.1, KV1.2, and their cytoplasmic KVβ2 subunit, which may help in axon conduction stabilization and the maintenance of the internodal resting potential1. Caspr2 is essential for the targeted localization of these channels in the juxtaparanodal regions. Indeed, targeted disruption of Caspr2 resulted in a marked reduction in the accumulation of K+ channels at the juxtaparanodes in both peripheral and central nervous system axons3.Moreover, mutations in the Caspr2 gene have been implicated in multiple neurodevelopmental disorders, including Tourette syndrome, schizophrenia, epilepsy, autism, attention-deficit hyperactivity disorder and mental retardation4-6.
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基因ID
- 26047
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NCBI登录号
- NM_014141
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UniProt
- Q9UHC6
抗原
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