CRMP1 抗体 (Intracellular)
Our Local Distributor
北京 101111
Quick Overview for CRMP1 抗体 (Intracellular) (ABIN7043080)
抗原
See all CRMP1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 481-496, Intracellular
-
原理
- A Rabbit Polyclonal Antibody to CRMP-1
-
交叉反应
- 人, 小鼠, 大鼠
-
预测反应
- Mouse - identical, human - 12,16 amino acid residues identical
-
产品特性
- Anti-CRMP1 Antibody (ABIN7043080, ABIN7044540 and ABIN7044541) is a highly selective antibody directed against an epitope of the rat protein. The antibody can be used in western blot analysis. It has been designed to recognize from human, mouse, and rat samples.
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
- (C)RVRIRSKVFGLHSVSR, corresponding to amino acid residues 481-496 of rat CRMP1
-
亚型
- IgG
-
-
anti-Collapsin Response Mediator Protein 1 (CRMP1) antibody
KD Validated CRMP1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB2215 unconjugated Recombinant Antibody
anti-Collapsin Response Mediator Protein 1 (CRMP1) (AA 221-310) antibodyCRMP1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2B6 unconjugated
anti-Collapsin Response Mediator Protein 1 (CRMP1) (N-Term) antibodyCRMP1 适用: 人, 小鼠, 大鼠, 犬, Cow, 斑马鱼, 豚鼠, 马, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Collapsin Response Mediator Protein 1 (CRMP1) (AA 1-250) antibodyCRMP1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Collapsin Response Mediator Protein 1 (CRMP1) (AA 82-110), (N-Term) antibodyCRMP1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB33780 unconjugated
anti-Collapsin Response Mediator Protein 1 (CRMP1) (C-Term) antibodyCRMP1 适用: 人, 小鼠, 大鼠, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-Collapsin Response Mediator Protein 1 (CRMP1) (C-Term) antibodyCRMP1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Collapsin Response Mediator Protein 1 (CRMP1) (AA 1-572) antibodyCRMP1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Collapsin Response Mediator Protein 1 (CRMP1) (AA 148-389) antibodyCRMP1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Collapsin Response Mediator Protein 1 (CRMP1) antibodyCRMP1 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
-
-
应用备注
-
WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
-
说明
-
Negative Control: (ABIN7235158)
Blocking Peptide: (ABIN7235158)
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
-
浓度
- 0.8 mg/mL
-
缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
-
-
- CRMP1 (Collapsin Response Mediator Protein 1 (CRMP1))
-
别名
- CRMP1
-
背景
-
Synonyms: CRMP-1, Collapsin response mediator protein 1, Dihydropyrimidinase-related protein 1, DRP-1, Dpysl1, Dihydropyrimidinase-like 1, Ulip3, Unc-33-like phosphoprotein 3
Description: Collapsin response mediator proteins (CRMPs) are a family of cytosolic phosphoproteins that were originally identified in developing nervous tissue. They are characterized as intracellular mediators of Semaphorin 3A signaling pathway, which is involved in axon differentiation during neural development.The CRMP family includes five members, CRMP-1 to CRMP-5. All five isoforms share a significant similarity in sequence with liver dihydropyrimidinase (DHPase) and with each other. CRMP-1 to CRMP-4 share 75 % identical sequence, while CRMP-5 shares 50 % identity with the other CRMPs.CRMP-1 is involved in cortical neuronal migration through reelin signaling. CRMP-1 inhibits the migration and invasion of non-small cell lung cancer (NSCLC). CRMP-1 includes a long form isoform, LCRMP-1, which promotes filopodia formation, cancer cell migration and invasion, resulting in poor clinical outcomes in NSCLC patients, therefore the long form is considered to be an invasion enhancer in NSCLC1-3.Human CRMP-1 overall structure is very similar to mouse CRMP-1. The human protein generally comprises a heterotetrameric assembly with a randomly coiled link that connects the protomers to each other. The proteins can form homotetramers when purified from bovine brain. CRMPs contains a positively charged C-terminal region that is highly susceptible to proteolysis2,3.
-
基因ID
- 25415
-
NCBI登录号
- NM_001313
-
UniProt
- Q62950
抗原
-
