CHRM3 抗体 (3rd Intracellular Loop)
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Quick Overview for CHRM3 抗体 (3rd Intracellular Loop) (ABIN7043063)
抗原
See all CHRM3 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- 3rd Intracellular Loop, AA 461-479
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原理
- A Rabbit Polyclonal Antibody to Muscarinic Acetylcholine Receptor M3
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Human,mouse,bovine,pig - identical
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产品特性
- Anti-CHRM3 Antibody (ABIN7043063, ABIN7044588 and ABIN7044589) is a highly specific antibody directed against an epitope of the rat M3 muscarinic receptor. The antibody can be used in western blot, immunohistochemistry, immunocytochemistry, and immunoprecipitation applications. It has been designed to recognize M3 from human, mouse, and rat samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)TLAKRFALKTRSQITKRKR, corresponding to amino residues 461-479 of rat M3
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亚型
- IgG
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anti-Cholinergic Receptor, Muscarinic 3 (CHRM3) antibody
CHRM3 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 4A6B7 unconjugated
anti-Cholinergic Receptor, Muscarinic 3 (CHRM3) (AA 481-589) antibodyCHRM3 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cholinergic Receptor, Muscarinic 3 (CHRM3) (AA 1-67) antibodyCHRM3 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Cholinergic Receptor, Muscarinic 3 (CHRM3) (AA 270-470) antibodyCHRM3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cholinergic Receptor, Muscarinic 3 (CHRM3) (3rd Cytoplasmic Domain) antibodyCHRM3 适用: 人, 小鼠 IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cholinergic Receptor, Muscarinic 3 (CHRM3) (AA 1-590) antibodyCHRM3 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Cholinergic Receptor, Muscarinic 3 (CHRM3) (Cytoplasmic Domain) antibodyCHRM3 适用: 人, 大鼠, 小鼠, 猴, 马, 绵羊, 兔, Pig, Hamster, 犬, Cow, Bat, 豚鼠 ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cholinergic Receptor, Muscarinic 3 (CHRM3) (Cytoplasmic Domain) antibodyCHRM3 适用: 人, 大鼠, 小鼠, 猴, 马, 绵羊, 兔, Pig, Hamster, 犬, Cow, Bat ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cholinergic Receptor, Muscarinic 3 (CHRM3) (Cytoplasmic Domain) antibodyCHRM3 适用: 人, 猴 ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cholinergic Receptor, Muscarinic 3 (CHRM3) (AA 253-492) antibodyCHRM3 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: 1:200
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Cited Application: IHC
Negative Control: (ABIN7235122)
Blocking Peptide: (ABIN7235122)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- CHRM3 (Cholinergic Receptor, Muscarinic 3 (CHRM3))
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别名
- CHRM3
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背景
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Synonyms: Cholinergic muscarinic receptor 3, Muscarinic acetylcholine receptor M3, M3 mAChR
Description: The action of the neurotransmitter acetylcholine is mediated through two types of receptors, the ionotrophic nicotinic receptors and the metabotrophic muscarinic receptors. The muscarinic receptors belong to the superfamily of 7-TM G-protein-coupled receptors. Five subtypes of muscarinic receptors have been cloned and named m1-m5.1-2The muscarinic receptors are widely distributed throughout the body, but are predominantly expressed within the parasympathetic nervous system and exerts both excitatory and inhibitory control over central and peripheral tissues.1-2 The m3 receptor is expressed in brain, heart, urinary bladder, salivary gland and airway smooth muscle.3Muscarinic receptors participate in a number of physiologic functions such as regulation of heart rate, muscle contraction, cognition, sensory processing and motor control.1 They also participate in learning and memory processing.4-5 The m1 receptors are the most abundant muscarinic subtype in the cortex and striatum. m1 receptors were also localized in the myenteric plexus where they function as autoreceptors to enhance the release of Ach from the nerves.6-7 m2, found in heart, is coupled to and mediates the slowing of heart rate in response to acetylcholine.3,8 m3 controls smooth muscle contraction and its stimulation causes secretion from glandular tissues.9Involvement of muscarinic receptors in apoptosis and cell growth has been reported.10-14 m1, m3 and m5, which are coupled to Gq/11 proteins, can protect cells from undergoing apoptosis induced by DNA damage. The signaling mechanism that mediates this anti-apoptotic response is still poorly understood. However, it was recently reported that a poly-basic motif in the C-terminus tail of the m3, m1 and m5 receptors is an essential element for the anti-apoptotic response of those receptors.10Muscarinic receptors are also capable of promoting cell proliferation in many cell types, however, the signaling pathways are yet, unclear.11-14 In the literature, m3 was reported to be involved in mitogenesis and proliferation of different cell types. Recently, it was reported that activation of the m3 muscarinic receptor induces significant proliferation of colon and prostate cancer cells.11-14
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基因ID
- 24260
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NCBI登录号
- NM_000740
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UniProt
- P08483
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途径
- Synaptic Membrane
抗原
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