CHRM1 抗体 (Intracellular)
Quick Overview for CHRM1 抗体 (Intracellular) (ABIN7043061)
抗原
See all CHRM1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 443-458, Intracellular
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原理
- A Rabbit Polyclonal Antibody to Muscarinic Acetylcholine Receptor M1
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特异性
- Intracellular, C-terminus
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,rat - identical
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产品特性
- Anti-CHRM1 (443-458) Antibody (ABIN7043061, ABIN7044590 and ABIN7044591) is a highly specific antibody directed against an epitope of the human M1 muscarinic receptor. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize M1 receptor from mouse, rat, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)RKIPKRPGSVHRTPSR, corresponding to amino acid residues 443-458 of human M1 muscarinic receptor
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亚型
- IgG
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anti-Muscarinic Acetylcholine Receptor M1 (CHRM1) (AA 210-363) antibody
CHRM1 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Muscarinic Acetylcholine Receptor M1 (CHRM1) (C-Term) antibodyCHRM1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Muscarinic Acetylcholine Receptor M1 (CHRM1) (AA 321-420) antibodyCHRM1 适用: 大鼠, 人, 小鼠, 山羊 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Muscarinic Acetylcholine Receptor M1 (CHRM1) (C-Term) antibodyCHRM1 适用: 大鼠, 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Muscarinic Acetylcholine Receptor M1 (CHRM1) (C-Term) antibodyVerified CHRM1 适用: 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Muscarinic Acetylcholine Receptor M1 (CHRM1) (C-Term) antibodyCHRM1 适用: 大鼠, 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Muscarinic Acetylcholine Receptor M1 (CHRM1) (AA 227-353) antibodyKO Validated CHRM1 适用: 人 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Muscarinic Acetylcholine Receptor M1 (CHRM1) (AA 210-366) antibodyCHRM1 适用: 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Muscarinic Acetylcholine Receptor M1 (CHRM1) (AA 331-367), (C-Term) antibodyCHRM1 适用: 小鼠 WB 宿主: 兔 Polyclonal RB51455 unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100
Application Dilutions Western blot wb: 1:200
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- CHRM1 (Muscarinic Acetylcholine Receptor M1 (CHRM1))
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别名
- CHRM1
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背景
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Cholinergic muscarinic receptor 1, Muscarinic acetylcholine receptor M1,The action of the neurotransmitter acetylcholine (ACh) is mediated through two types of receptors, the ionotrophic nicotinic receptors and the metabotrophic muscarinic receptors. The muscarinic receptors belong to the superfamily of 7-TM G-protein-coupled receptors. Five subtypes of muscarinic receptors have been cloned and named M1-M5.1-2The muscarinic receptors are widely distributed throughout the body, but are predominantly expressed within the parasympathetic nervous system and exert both excitatory and inhibitory control over central and peripheral tissues.1-2Muscarinic receptors participate in a number of physiological functions such as regulation of heart rate, muscle contraction, cognition, sensory processing and motor control.1 They also participate in learning and memory processing.3-4 The M1 receptors are the most abundant muscarinic subtype in the cortex and striatum. M1 receptors were also localized in the myenteric plexus where they function as autoreceptors to enhance the release of ACh from the nerves.5-6The M1, M3 and M5 receptors, which are coupled to Gq/11 proteins, can protect cells from undergoing apoptosis induced by DNA damage. The signaling mechanism that mediates this anti-apoptotic response is still poorly understood. However, it was recently reported that a poly-basic motif in the C-terminus tail of the M1, M3 and M5 receptors is an essential element for the anti-apoptotic response of those receptors.7
Alternative names: M1 Muscarinic Receptor, CHRM1, Cholinergic muscarinic receptor 1, Muscarinic acetylcholine receptor M1 -
基因ID
- 1128
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NCBI登录号
- NM_000738
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UniProt
- P11229
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途径
- Synaptic Membrane
抗原
-
