CLCN2 抗体 (Intracellular)
Quick Overview for CLCN2 抗体 (Intracellular) (ABIN7043051)
抗原
See all CLCN2 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
-
-
抗原表位
- AA 888-906, Intracellular
-
原理
- A Rabbit Polyclonal Antibody to CLC-2 (CLCN2) Channel
-
特异性
- Intracellular, C-terminus
-
交叉反应
- 人, 小鼠, 大鼠
-
预测反应
- human - 17, guinea pig - 15,swine - 18,19 amino acid residues identical,Mouse - identical, rabbit
-
产品特性
- Anti- (CLCN2) Antibody (ABIN7043051 and ABIN7044123) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, immunohistochemistry and immunocytochemistry applications. It has been designed to recognize channel from rat, mouse, and human samples.
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
-
Immunogen: Synthetic peptide
Immunogen Sequence: RSRHGLPREGTPSDSDDKC, corresponding to amino acid residues 888-906 of rat CLC-2.
-
亚型
- IgG
-
-
anti-Chloride Channel 2 (CLCN2) (AA 38-387) antibody
CLCN2 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 3E1 unconjugated
anti-Chloride Channel 2 (CLCN2) (AA 549-770) antibodyCLCN2 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Chloride Channel 2 (CLCN2) (C-Term) antibodyCLCN2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chloride Channel 2 (CLCN2) (Internal Region) antibodyVerified CLCN2 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Chloride Channel 2 (CLCN2) (C-Term) antibodyCLCN2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Chloride Channel 2 (CLCN2) (AA 208-237), (N-Term) antibodyCLCN2 适用: 人, 小鼠 WB, EIA 宿主: 兔 Polyclonal unconjugated
anti-Chloride Channel 2 (CLCN2) (AA 209-237), (N-Term) antibodyCLCN2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
-
说明
-
Negative Control: (ABIN7235082)
Blocking Peptide: (ABIN7235082)
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- 0.2 mL double distilled water (DDW).
-
浓度
- 1 mg/mL
-
缓冲液
- PBS pH 7.4
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
-
-
- CLCN2 (Chloride Channel 2 (CLCN2))
-
别名
- CLCN2
-
背景
-
Chloride channel 2, ClC2,CLC-2 is a member of the voltage-dependent Cl- channel (CLC) family that includes nine known members in mammals. CLC channels can be classified as plasma membrane channels and intracellular organelle channels. The first group includes the CLC-1, CLC-2 CLC-Ka and CLCKb channels. The second group comprises the CLC-3, CLC-4, CLC-5, CLC-6 and CLC-7.CLC channels that function in the plasma membrane are involved in the stabilization of membrane potential and in transepithelial transport. The presumed function of the intracellular CLC channels is support of the acidification of the intraorganellar compartment. In this regard, recent reports indicate that ClC-4 and ClC-5 (and by inference ClC-3) can function as Cl-/H+ antiporters.1, 2The functional unit of the CLC channels is a dimer with each subunit forming a proper pore. Although the crystal structure of bacterial CLC channels was resolved, the topology of the CLC channels is complex and has not been fully elucidated. It is generally accepted that both the N- and C- terminus domains are intracellular while the number and configuration of the transmembrane domains vary greatly between different models. 1,2CLC-2 is widely distributed with prominent expression in brain, kidney, lung and the gastrointestinal system. Mutations in the CLC-2 channel gene detected in humans are associated with idiopathic generalized epilepsies while disruption of the ClC-2 gene in mice is associated with testicular and retinal degeneration. 3,4
Alternative names: CLC-2 (CLCN2), Chloride channel 2, ClC2 -
基因ID
- 29232
-
NCBI登录号
- NM_001171087
-
UniProt
- P35525
抗原
-
