CMKLR1 抗体 (Extracellular)
Quick Overview for CMKLR1 抗体 (Extracellular) (ABIN7043049)
抗原
See all CMKLR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 201-215, Extracellular
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原理
- A Rabbit Polyclonal Antibody to Chemerin Receptor 1
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特异性
- 2nd extracellular loop
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交叉反应 （详细）
- Will unlikely recognize CMKLR1 from human and mouse samples.
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预测反应
- Rat only
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产品特性
- Anti-Rat CMKLR1 (extracellular) Antibody (ABIN7043049, ABIN7044179 and ABIN7044180) is a highly specific antibody directed against an epitope of rat Chemerin receptor 1. It can be used in western blot and immunohistochemistry applications. It has been designed to recognize the protein from rat samples only. The antibody is unlikely to recognize the receptor from human and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)HSTHPRTDPVGYSRH, corresponding to amino acid residues 201-215 of rat Chemerin receptor 1
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亚型
- IgG
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anti-Chemokine-Like Receptor 1 (CMKLR1) (AA 321-373) antibody
CMKLR1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Chemokine-Like Receptor 1 (CMKLR1) (AA 151-250) antibodyCMKLR1 适用: 人, 小鼠, 大鼠, Pig WB, ELISA, IF (cc), IF (p), FACS, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine-Like Receptor 1 (CMKLR1) (AA 305-333), (C-Term) antibodyCMKLR1 适用: 人 WB 宿主: 兔 Polyclonal RB42353 unconjugated
anti-Chemokine-Like Receptor 1 (CMKLR1) (N-Term) antibodyCMKLR1 适用: 人, 犬, 猴, 兔 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine-Like Receptor 1 (CMKLR1) (AA 171-280) antibodyCMKLR1 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine-Like Receptor 1 (CMKLR1) (AA 8-32) antibodyCMKLR1 适用: 小鼠 WB, ELISA, IHC, IF, FACS, IP, Func 宿主: 兔 Chimeric BZ194 unconjugated Recombinant Antibody
anti-Chemokine-Like Receptor 1 (CMKLR1) (C-Term) antibodyCMKLR1 适用: 人, Pig, Cow, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Chemokine-Like Receptor 1 (CMKLR1) (AA 250-350) antibodyCMKLR1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Chemokine-Like Receptor 1 (CMKLR1) (AA 250-350) antibodyCMKLR1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Chemokine-Like Receptor 1 (CMKLR1) (C-Term) antibodyCMKLR1 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:300
Application Dilutions Western blot wb: 1:200
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))
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别名
- CMKLR1
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背景
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Chemokine-like receptor 1, Cmklr1, Chemerin1, Gpcr27, G-protein coupled receptor ChemR23, CHEMERINR, G-protein coupled chemoattractant-like receptor, G-protein coupled receptor DEZ,Chemerin Receptor 1 belongs to class A G-protein coupled receptors. The receptor is coupled to Gi/o, leading to an increase in intracellular cAMP and Ca2+ following activation by the binding of Chemerin, its endogenous ligand. Like all GPCRs, it has seven transmembrane domains, an extracellular N-terminus and intracellular C-terminal tail1.Chemerin Receptor 1 has numerous names depending on how the gene encoding the receptor was cloned: Chemokine-like receptor 1, CMKLR1, ChemR23 and others all correspond to the same gene/protein1.Expression of Chemerin receptor 1 at the mRNA level is largely detected in adipose tissue, and skin dermal layer. At the protein level, CMKLR1 is expressed at the cell surface of dendritic cells, monocytes and macrophages, smooth muscle cells, adipose tissue, lung, lymph nodes and testis1.A role for the receptor in the inflammatory response has been attributed, however data indicate contradictory roles, proinflammatory and anti-inflammatory functions of the receptor. Expression of Chemerin receptor 1 in adipose tissue clearly establishes its involvement in energy metabolism as an important regulator of adipogenesis1.
Alternative names: Rat CMKLR1, Chemokine-like receptor 1, Cmklr1, Chemerin1, Gpcr27, G-protein coupled receptor ChemR23, CHEMERINR, G-protein coupled chemoattractant-like receptor, G-protein coupled receptor DEZ -
基因ID
- 60669
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NCBI登录号
- NM_001142343
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UniProt
- O35786
抗原
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