CX3CL1 抗体 (Extracellular)
Quick Overview for CX3CL1 抗体 (Extracellular) (ABIN7043046)
抗原
See all CX3CL1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 6-19, Extracellular
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原理
- A Rabbit Polyclonal Antibody to CX3CR1 Chemokine Receptor
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特异性
- Extracellular, N-terminus
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交叉反应 （详细）
- The antibody will not recognize the protein from rat or mouse samples.
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预测反应
- Human only
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产品特性
- Anti-Human CX3CR1 (extracellular) Antibody (ABIN7043046, ABIN7044196 and ABIN7044197) is a highly specific antibody directed against an epitope of human CX3C chemokine receptor 1. The antibody can be used in western blot and indirect flow cytometry applications. It has been designed to recognize CX3CR1 from human samples only. The antibody will not recognize the protein from rat or mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)ESVTENFEYDDLAE, corresponding to amino acid residues 6-19 of human CX3CR1
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亚型
- IgG
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anti-Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1) (AA 25-332) antibody
CX3CL1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1) (AA 365-397) antibodyCX3CL1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1) (AA 301-397) antibodyCX3CL1 适用: 人, 大鼠, 小鼠 WB, ELISA, ICC, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1) antibodyCX3CL1 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1) (AA 25-100) antibodyCX3CL1 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1) (Internal Region) antibodyVerified CX3CL1 适用: 人 IHC, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1) (AA 81-336) antibodyCX3CL1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1) (N-Term) antibodyCX3CL1 适用: 人, 大鼠, 小鼠, Cow, 犬, 豚鼠, 马, 兔, Saccharomyces cerevisiae, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1) (AA 272-306) antibodyCX3CL1 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB56920 unconjugated
anti-Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1) (AA 83-330) antibodyCX3CL1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:600
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- CX3CL1 (Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1))
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别名
- CX3CL1
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背景
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Fractalkine Receptor, CX3C chemokine receptor 1, C-X3-C CKR-1, C-X3-C motif chemokine receptor 1, GPR13, CMKBRL1, GPRV28, V28, G-protein coupled receptor 13, CCRL1, Beta chemokine receptor-like 1,CX3C-chemokine receptor 1 (CX3CR1) is a 368 amino acid (aa) protein that contains seven-transmembrane domains and belongs to the family of G protein coupled receptors1.CX3CR1 has a central role in adhesion and chemotaxis through binding to its ligand, fractalkine CX3C chemokine ligand 1, (CX3CL1). The major role of CX3CR1 in immune cells is to recognize and enter inflamed tissue according to CX3CL1 gradient and initiate the innate immune system2. The receptor-ligand axis also mediates the crosstalk between glial cells and neurons by direct or indirect ways in the central nervous system (CNS)3. Expression and interaction of CX3CR1 with CX3CL1 is related to many diseases among which are asthma, cancer and gut infections (reviewed in 4).Both CX3CL1 and CX3CR1 are expressed throughout the body. However, their expression is highly cell type-specific depending on organs and tissues. In the brain, CX3CL1/CX3CR1 signaling can modulate the production of cytokines by microglia cells. It has been reported that CX3CL1/CX3CR1 signaling is associated with Alzheimer's disease5. In the liver, CX3CR1 is expressed in monocytes, CD8+ T cells, and natural killer (NK) cells. Besides immune cells, it is highly expressed at inflammatory sites4.
Alternative names: CX3CR1, CX3C chemokine receptor 1, C-X3-C CKR-1, C-X3-C motif chemokine receptor 1, GPR13, CMKBRL1, GPRV28, V28, G-protein coupled receptor 13, CCRL1, Beta chemokine receptor-like 1 -
基因ID
- 1524
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NCBI登录号
- NM_002996
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UniProt
- P49238
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途径
- Synaptic Membrane
抗原
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