CX3CL1 抗体 (Extracellular, N-Term)
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Quick Overview for CX3CL1 抗体 (Extracellular, N-Term) (ABIN7043045)
抗原
See all CX3CL1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 58-71, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to CX3CL1
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rat - identical, mouse - 12,14 amino acid residues identical
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产品特性
- Anti-CX3CL1 (extracellular) Antibody (ABIN7043045, ABIN7044192 and ABIN7044193) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot analysis. It has been designed to recognize CX3CL1 from human, mouse and rat samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- CGKRAIILETRQHR, corresponding to amino acid residues 58-71 of human CX3CL1
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亚型
- IgG
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anti-Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1) (AA 25-332) antibody
CX3CL1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1) (AA 365-397) antibodyCX3CL1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1) (AA 301-397) antibodyCX3CL1 适用: 人, 大鼠, 小鼠 WB, ELISA, ICC, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1) antibodyCX3CL1 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1) (Internal Region) antibodyVerified CX3CL1 适用: 人 IHC, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1) (AA 25-100) antibodyCX3CL1 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1) (AA 81-336) antibodyCX3CL1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1) (N-Term) antibodyCX3CL1 适用: 人, 大鼠, 小鼠, Cow, 犬, 豚鼠, 马, 兔, Saccharomyces cerevisiae, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1) (AA 272-306) antibodyCX3CL1 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB56920 unconjugated
anti-Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1) (AA 83-330) antibodyCX3CL1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:400
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:200
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235071)
Blocking Peptide: (ABIN7235071)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- CX3CL1 (Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1))
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别名
- CX3CL1
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背景
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Synonyms: Fractalkine, C-X3-C motif chemokine 1, CX3C membrane-anchored chemokine, Neurotactin, Small-inducible cytokine D1, FKN, NTT, SCYD1
Description: CX3C chemokine ligand 1 (CX3CL1), also known as fractalkine (FKN), is a chemokine belonging to the CX3C family. CX3CL1 is secreted by neurons and plays an important role in modulating glial activation in the central nervous system after binding to its sole receptor CX3CR1 which mainly is expressed on microglia. The CX3CL1/CX3CR1 interaction is an important bridge connecting neuron and microglia1.CX3CL1 is a large cytokine protein with an extended mucin-like stalk and a chemokine domain at the N-terminus. It is the only member of CX3C family which belongs to the large family of small secreted chemotactic cytokines. CX3CL1 is highly and constitutively expressed in hippocampal and cortical neurons. It exists in both secreted and membrane-bound form. While the secreted form contains only the chemokine domain located in the N-terminus, the membrane-bound form contains the chemokine domain, a mucin-like stalk, a transmembrane domain and an intracellular C-terminal domain. The membrane-tethered mucin stalk acts as a cell adhesion molecule adhering to microglia during an inflammatory reaction, it can be cleaved to produce a soluble glycoprotein by metalloproteinases ADAM 10 and ADAM 17 or lysosomal cysteine protease and cathepsin S (CatS), The soluble form has been proposed to act as a chemoattractant and can serve as a signaling molecule mediating neural/microglial interactions via its receptor CX3CR1, mainly expressed on microglia and partly on astrocyte as well as on neurons in the CNS. The CX3CL1/CX3CR1 interaction on microglia is likely to alter the microglial state to a more neuroprotective one. Notably, transmembrane and soluble CX3CL1 elicit different cytokine responses in immune cells1-3.CX3CL1 has been associated with learning and memory as CX3CL1 is upregulated in the rat hippocampus during memory-associated synaptic plasticity. It is considered as a potent neuromodulator of the evoked excitatory synaptic transmission and plays a major role in synaptic plasticity and neuroprotection1,4.
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基因ID
- 6376
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NCBI登录号
- NM_002996
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UniProt
- P78423
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途径
- Synaptic Membrane
抗原
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