CXCR5 抗体 (Extracellular)
Quick Overview for CXCR5 抗体 (Extracellular) (ABIN7043042)
抗原
See all CXCR5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 23-38, Extracellular
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原理
- A Rabbit Polyclonal Antibody to CXCR5 Chemokine Receptor
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特异性
- Extracellular, N-terminus
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交叉反应 （详细）
- Will not recognize rat and mouse CXCR5.
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预测反应
- Human only
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产品特性
- Anti-Human CXCR5 (extracellular) Antibody is directed against an epitope of the human CXCR5. Anti-Human CXCR5 (extracellular) Antibody (ABIN7043042, ABIN7044168 and ABIN7044169) can be used in western blot, immunocytochemistry, and indirect flow cytometry applications. The antibody recognizes an extracellular epitope and is thus ideal for detecting the receptor in living cells. It has been designed to recognize CXCR5 from human samples only.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: RLDNYNDTSLVENHLC, corresponding to amino acid residues 23-38 of human CXCR5
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亚型
- IgG
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anti-Chemokine (C-X-C Motif) Receptor 5 (CXCR5) (AA 1-55) antibody
CXCR5 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Receptor 5 (CXCR5) antibodyCXCR5 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Chemokine (C-X-C Motif) Receptor 5 (CXCR5) (AA 281-372) antibodyCXCR5 适用: 人, 小鼠 WB, ELISA, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Receptor 5 (CXCR5) (N-Term) antibodyCXCR5 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Receptor 5 (CXCR5) (AA 1-30), (N-Term) antibodyCXCR5 适用: 人 WB 宿主: 兔 Polyclonal RB41684 unconjugated
anti-Chemokine (C-X-C Motif) Receptor 5 (CXCR5) (Cytoplasmic Domain) antibodyCXCR5 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Receptor 5 (CXCR5) (AA 1-372) antibodyCXCR5 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Receptor 5 (CXCR5) (AA 1-55) antibodyCXCR5 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2C1 unconjugated
anti-Chemokine (C-X-C Motif) Receptor 5 (CXCR5) (N-Term) antibodyCXCR5 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Receptor 5 (CXCR5) (C-Term) antibodyCXCR5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:400
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- CXCR5 (Chemokine (C-X-C Motif) Receptor 5 (CXCR5))
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别名
- CXCR5
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背景
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C-X-C chemokine receptor type 5, Burkitt lymphoma receptor 1, BLR1, Monocyte-derived receptor 15, MDR15, CD185,Chemokine receptors are a family of receptors that signal upon binding of one or more members of the chemokine superfamily of chemotactic cytokines. Chemokines coordinate development, differentiation and trafficking of various immune system cells making them key players of the innate and adaptive immune response.CXCR5 (also known as Burkitt lymphoma receptor 1) belongs to the CXC subfamily of chemokine receptors and is a G-coupled protein receptor with 7 transmembrane segments. There is considerable homology between CXCR5 and other members of the chemokine receptor family such as IL-9 receptor, CCR-1 and BLR2. CXCR5 expression is detected in peripheral blood CD4 and CD8 leukocytes as well as in secondary lymphatic organs and in granule and Purkinje layers in the brain. It is also expressed in Burkitt's lymphoma cells1.CXCR5 is activated by B-cell attracting chemokine 1 (BCA-1) that is chemotactic for human B lymphocytes. BCA-1 does not affect IL-2 stimulated T-cells, monocytes or neutrophils2. CXCR5 mediates correct T cell localization within granulomas, efficient macrophage activation and lymphoid follicle formation3.CXCR5 knockout mice have a severe defect in normal B cell migration and localization. Knockout mice lack inguinal lymph nodes, have a reduced amount of Peyer's patches and have abnormal primary lymphoid follicles and no functional germinal centers in the spleen4. Absence of CXCR5 has been implicated in increased susceptibility to tuberculosis to due defective T cell localization within the lung3.
Alternative names: CXCR5, C-X-C chemokine receptor type 5, Burkitt lymphoma receptor 1, BLR1, Monocyte-derived receptor 15, MDR15, CD185 -
基因ID
- 643
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NCBI登录号
- NM_001716
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UniProt
- P32302
抗原
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