HCRTR2 抗体 (C-Term, Intracellular)
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Quick Overview for HCRTR2 抗体 (C-Term, Intracellular) (ABIN7886827)
抗原
See all HCRTR2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 391-405, C-Term, Intracellular
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原理
- A Rabbit Polyclonal Antibody to Orexin Receptor 2
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse - identical, human - 14,15 amino acid residues identical
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产品特性
- Anti-Orexin Receptor 2 Antibody (ABIN7043029, ABIN7044885 and ABIN7044886) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, immunocytochemistry, and immunohistochemistry applications. It has been designed to recognize OX2R from rat, mouse, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)DRLARGRTSTESRKS, corresponding to amino acid residues 391-405 of rat OX2R
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亚型
- IgG
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anti-Hypocretin (Orexin) Receptor 2 (HCRTR2) (AA 1-54) antibody
HCRTR2 适用: 人 ELISA, WB, RNAi 宿主: 小鼠 Monoclonal 1E3 unconjugated
anti-Hypocretin (Orexin) Receptor 2 (HCRTR2) (C-Term) antibodyHCRTR2 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Hypocretin (Orexin) Receptor 2 (HCRTR2) (N-Term) antibodyVerified HCRTR2 适用: 人 ELISA, WB 宿主: 山羊 Polyclonal unconjugated
anti-Hypocretin (Orexin) Receptor 2 (HCRTR2) antibodyHCRTR2 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hypocretin (Orexin) Receptor 2 (HCRTR2) (AA 380-444) antibodyHCRTR2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Hypocretin (Orexin) Receptor 2 (HCRTR2) (AA 275-304) antibodyHCRTR2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Hypocretin (Orexin) Receptor 2 (HCRTR2) (AA 1-444) antibodyHCRTR2 适用: 人 IP 宿主: 兔 Polyclonal unconjugated
anti-Hypocretin (Orexin) Receptor 2 (HCRTR2) (AA 405-419) antibodyVerified HCRTR2 适用: 小鼠 ELISA, WB 宿主: 山羊 Polyclonal unconjugated
anti-Hypocretin (Orexin) Receptor 2 (HCRTR2) (N-Term) antibodyHCRTR2 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hypocretin (Orexin) Receptor 2 (HCRTR2) antibodyHCRTR2 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200-1:400
FC: The optimal concentration should be determined by the user
ICC: 1:500
IHC: 1:50
IP: The optimal concentration should be determined by the user
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说明
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Cited Application: IFC
Negative Control: (ABIN7235047)
Blocking Peptide: (ABIN7235047)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- HCRTR2 (Hypocretin (Orexin) Receptor 2 (HCRTR2))
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别名
- HCRTR2
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背景
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Synonyms: OX2R, Hypocretin receptor type 2, HCRTR2
Description: Orexin Receptor 2 (OX2R) (also known as hypocretin receptor 2) is one of two receptors that recognize the peptide neurotransmitters orexin A and orexin B.1 Orexin A and B are 33 and 28 amino acids in length, respectively, and are derived from a common precursor termed prepro-orexin.OX2R binds both orexin A and B with similar affinities while OX1R binds orexin A with greater affinity than orexin B (a one order of magnitude difference).2,3Both OX2R and OX1R belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. OX2R is thought to transmit signals through the Ga11 class of G proteins, resulting in the activation of phospholipase C with subsequent triggering of the phosphatidylinositol cascade and an influx of extracellular Ca2+, probably through transient receptor potential (TRP) channels. OX2R can also transmit signals through inhibitory Gi G proteins, although the mechanism is less well understood.2,3The physiological functions of the orexin system (OX1R, OX2R, and their ligands) have been a matter of intense research over the last few years. OX2R is expressed in both the central nervous system and peripheral locations such as gastrointestinal tissues, pancreas, and testis.2The best studied physiological role of OX2R is its involvement in the regulation of sleep and wakefulness states. Studies in mice lacking the orexin gene and dogs expressing a null mutation of the OX2R show a remarkably similar phenotype to human narcolepsy, a condition characterized by excessive daytime sleepiness, inability to maintain vigilant states, and defects in the regulation of rapid eye movement (REM) sleep.4In addition, the orexin system is involved in regulating autonomic functions such as blood pressure and heart rate, as well as in mechanisms that regulate the reward response in the brain.4
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基因ID
- 25605
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NCBI登录号
- NM_001384272
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UniProt
- P56719
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途径
- Feeding Behaviour
抗原
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