CNR2 抗体 (Extracellular, N-Term)
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Quick Overview for CNR2 抗体 (Extracellular, N-Term) (ABIN7043026)
抗原
See all CNR2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 11-24, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to Cannabinoid Receptor 2
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交叉反应 （详细）
- Not recommended to use with rat and mouse samples.
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预测反应
- Canis,bovine - 10,14 amino acid residues identical
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产品特性
- Anti-Human Cannabinoid Receptor 2 (extracellular) Antibody is directed against an extracellular epitope of the human CB2 receptor. Anti-Human Cannabinoid Receptor 2 (extracellular) Antibody (ABIN7043026, ABIN7044159 and ABIN7044160) can be used in western blot, immunohistochemistry and live cell imaging applications. It has been designed to recognize CB2 from human samples. The antibody is not recommended for use on rat and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)NGSKDGLDSNPMKD, corresponding to amino acid residues 11-24 of human CB2 receptor
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亚型
- IgG
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anti-Cannabinoid Receptor 2 (CNR2) (AA 329-356), (C-Term) antibody
CNR2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21841 unconjugated
anti-Cannabinoid Receptor 2 (CNR2) (AA 251-350) antibodyCNR2 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 2 (CNR2) (AA 302-360) antibodyCNR2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3C7 unconjugated
anti-Cannabinoid Receptor 2 (CNR2) (AA 329-356) antibodyCNR2 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 2 (CNR2) (C-Term) antibodyVerified CNR2 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Cannabinoid Receptor 2 (CNR2) (AA 305-360) antibodyCNR2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 2 (CNR2) (3rd Intracellular Loop), (AA 228-242) antibodyCNR2 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 2 (CNR2) (C-Term) antibodyCNR2 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 2 (CNR2) (Cytoplasmic Domain) antibodyCNR2 适用: 人, 猴, 犬 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 2 (CNR2) (AA 331-360), (C-Term) antibodyCNR2 适用: 人 WB, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: 2.5 μg per reaction
ICC: 1:50
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- CNR2 (Cannabinoid Receptor 2 (CNR2))
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别名
- CNR2
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背景
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Synonyms: CB2, CNR2
Description: Cannabinoids have been used as pain relievers in Eastern medicine for many years.1 To date, two specific cannabinoid receptors have been identified: cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2).2 The cannabinoid receptors can be distinguished by their amino acid sequence, signaling mechanisms and tissue distribution.2 Both receptors belong to the G-protein coupled receptor superfamily and are coupled to Gi/0 G protein.2,3The CB2 is highly expressed in cells of the immune system such as macrophages, lymphocytes natural killer cells and mast cells but has also been shown to be expressed, by both, in situ-hybridization and in immunohistochemistry, in spleen, thymus, and pancreas.1,2,4 CB2 expression in brain is still much less characterized than that of CB1. Recently, it was demonstrated that CB2 is expressed in the brain and might have a role in controlling fundamental processes such as proliferation and survival of neural cells.5,6Overexpression of CB2 was reported in several cancers such as prostate, glioma and acute myeloid leukemias.7-9 In human astrocytoma a direct relation between CB2 expression and tumor malignancy was demonstrated.8 Activation of CB2R in vivo by its agonist JWH-133, completely blocked cell growth.8 In C6 glioma, it was shown that activation of the CB2 by JWH-133 resulted in internalization of only the CB2 and not CB1 leading to apoptosis of the cells. This may well be a new approach for the treatment of glioma.
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基因ID
- 1269
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NCBI登录号
- NM_001841
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UniProt
- P34972
抗原
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