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- 抗原 See all CNR2 抗体
- CNR2 (Cannabinoid Receptor 2 (CNR2))
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抗原表位
- AA 228-242
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CNR2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 原理
- A Rabbit Polyclonal Antibody to Cannabinoid Receptor 2
- 特异性
- 3rd intracellular loop
- 交叉反应
- 小鼠, 大鼠
- 预测反应
- Mouse - identical Human - 14 out of 15 amino acid residues identical
- 产品特性
- Anti-Cannabinoid Receptor 2 Antibody (ABIN7043025, ABIN7044157 and ABIN7044158) is directed against an intracellular epitope of the rat CB2 receptor. Anti-Cannabinoid Receptor 2 Antibody (ABIN7043025, ABIN7044157 and ABIN7044158) can be used in western blot and immunohistochemistry applications, and recognizes CB2 in rat samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)DRQVPGIARMRLDVR, corresponding to amino acid residues 228-242 of rat CB2 receptor
- 亚型
- IgG
- Top Product
- Discover our top product CNR2 Primary Antibody
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anti-Cannabinoid Receptor 2 (CNR2) (AA 329-356), (C-Term) antibody
CNR2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21841 unconjugated
anti-Cannabinoid Receptor 2 (CNR2) (AA 251-350) antibodyCNR2 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 2 (CNR2) (AA 302-360) antibodyCNR2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3C7 unconjugated
anti-Cannabinoid Receptor 2 (CNR2) (AA 329-356) antibodyCNR2 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 2 (CNR2) (AA 305-360) antibodyCNR2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 2 (CNR2) (C-Term) antibodyVerified CNR2 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Cannabinoid Receptor 2 (CNR2) (Cytoplasmic Domain) antibodyCNR2 适用: 人, 猴, 犬 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 2 (CNR2) (C-Term) antibodyCNR2 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 2 (CNR2) (AA 1-100) antibodyCNR2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 2 (CNR2) (AA 11-24), (Extracellular) antibodyCNR2 适用: 人 WB, FACS, IF, IC, LCI 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100-1:400
Application Dilutions Western blot wb: 1:200
- 说明
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Cited Application: IHC
Negative Control: (ABIN7235032)
Blocking Peptide: (ABIN7235032)
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- 0.2 mL double distilled water (DDW).
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- CNR2 (Cannabinoid Receptor 2 (CNR2))
- 别名
- CNR2 (CNR2 产品)
- 背景
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CB2, CNR2,Cannabinoids have been used as pain relievers in Eastern medicine for many years.1 To date, two specific cannabinoid receptors have been identified: cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2).2 The cannabinoid receptors can be distinguished by their amino acid sequence, signaling mechanisms and tissue distribution.2 Both receptors belong to the G-protein coupled receptor superfamily and are coupled to Gi/0 G protein.2,3The CB2 receptor is highly expressed in cells of the immune system such as macrophages, lymphocytes natural killer cells and mast cells but has also been shown to be expressed, by both, in situ-hybridization and in immunohistochemistry, in spleen, thymus, and pancreas.1,2,4 CB2 expression in the brain is still much less characterized than that of CB1. Recently, it was demonstrated that CB2 is expressed in the brain and might have a role in controlling fundamental processes such as proliferation and survival of neural cells.5,6Overexpression of CB2 was reported in several cancers such as prostate, glioma and acute myeloid leukemias.6 In human astrocytoma a direct relationship between CB2 expression and tumor malignancy was demonstrated. Activation of CB2 in vivo by its agonist JWH-133, completely blocked cell growth. In C6 glioma, it was shown that activation of the CB2 by JWH-133 resulted in the internalization of only the CB2 and not CB1 leading to apoptosis of the cells. This may well be a new approach for the treatment of glioma.7
Alternative names: Cannabinoid Receptor 2, CB2, CNR2 - 基因ID
- 57302
- NCBI登录号
- NM_001841
- UniProt
- Q9QZN9
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