CNR2 抗体 (3rd Intracellular Loop)
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Quick Overview for CNR2 抗体 (3rd Intracellular Loop) (ABIN7043025)
抗原
See all CNR2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- 3rd Intracellular Loop, AA 228-242
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原理
- A Rabbit Polyclonal Antibody to Cannabinoid Receptor 2
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交叉反应
- 小鼠, 大鼠
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预测反应
- Mouse - identical Human - 14 out of 15 amino acid residues identical
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产品特性
- Anti-Cannabinoid Receptor 2 Antibody (ABIN7043025, ABIN7044157 and ABIN7044158) is directed against an intracellular epitope of the rat CB2 receptor. Anti-Cannabinoid Receptor 2 Antibody (ABIN7043025, ABIN7044157 and ABIN7044158) can be used in western blot and immunohistochemistry applications, and recognizes CB2 in rat samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)DRQVPGIARMRLDVR, corresponding to amino acid residues 228-242 of rat CB2 receptor
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亚型
- IgG
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anti-Cannabinoid Receptor 2 (CNR2) (AA 329-356), (C-Term) antibody
CNR2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21841 unconjugated
anti-Cannabinoid Receptor 2 (CNR2) (AA 251-350) antibodyCNR2 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 2 (CNR2) (AA 302-360) antibodyCNR2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3C7 unconjugated
anti-Cannabinoid Receptor 2 (CNR2) (AA 329-356) antibodyCNR2 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 2 (CNR2) (C-Term) antibodyVerified CNR2 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Cannabinoid Receptor 2 (CNR2) (AA 305-360) antibodyCNR2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 2 (CNR2) (AA 11-24), (Extracellular), (N-Term) antibodyCNR2 适用: 人 WB, FACS, IF, IC, LCI 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 2 (CNR2) (C-Term) antibodyCNR2 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 2 (CNR2) (Cytoplasmic Domain) antibodyCNR2 适用: 人, 猴, 犬 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cannabinoid Receptor 2 (CNR2) (AA 331-360), (C-Term) antibodyCNR2 适用: 人 WB, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:100-1:400
IP: The optimal concentration should be determined by the user
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说明
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Cited Application: IHC
Negative Control: (ABIN7235032)
Blocking Peptide: (ABIN7235032)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- CNR2 (Cannabinoid Receptor 2 (CNR2))
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别名
- CNR2
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背景
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Synonyms: CB2, CNR2
Description: Cannabinoids have been used as pain relievers in Eastern medicine for many years.1 To date, two specific cannabinoid receptors have been identified: cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2).2 The cannabinoid receptors can be distinguished by their amino acid sequence, signaling mechanisms and tissue distribution.2 Both receptors belong to the G-protein coupled receptor superfamily and are coupled to Gi/0 G protein.2,3The CB2 receptor is highly expressed in cells of the immune system such as macrophages, lymphocytes natural killer cells and mast cells but has also been shown to be expressed, by both, in situ-hybridization and in immunohistochemistry, in spleen, thymus, and pancreas.1,2,4 CB2 expression in the brain is still much less characterized than that of CB1. Recently, it was demonstrated that CB2 is expressed in the brain and might have a role in controlling fundamental processes such as proliferation and survival of neural cells.5,6Overexpression of CB2 was reported in several cancers such as prostate, glioma and acute myeloid leukemias.6 In human astrocytoma a direct relationship between CB2 expression and tumor malignancy was demonstrated. Activation of CB2 in vivo by its agonist JWH-133, completely blocked cell growth. In C6 glioma, it was shown that activation of the CB2 by JWH-133 resulted in the internalization of only the CB2 and not CB1 leading to apoptosis of the cells. This may well be a new approach for the treatment of glioma.7
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基因ID
- 57302
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NCBI登录号
- NM_001841
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UniProt
- Q9QZN9
抗原
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