CACNA2D4 抗体 (Extracellular)
Our Local Distributor
北京 101111
Quick Overview for CACNA2D4 抗体 (Extracellular) (ABIN7043016)
抗原
See all CACNA2D4 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 881-896, Extracellular
-
原理
- A Rabbit Polyclonal Antibody to CACNA2D4 (CaVα2δ4) Subunit
-
特异性
- Extracellular
-
交叉反应
- 小鼠, 大鼠
-
预测反应
- Rat - 15,16 amino acid residues identicalHuman - not recommended for use with human samples
-
产品特性
- Anti-CACNA2D4 (CaVα2δ4) (extracellular) Antibody (ABIN7043016 and ABIN7044046) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot, immunocytochemistry and immunohistochemistry applications. It is especially suited to detect CaVα2δ4 in living cells. It has been designed to recognize CaVα2δ4 from rat and mouse samples.
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
-
Immunogen: Synthetic peptide
Immunogen Sequence: (C)SERPQEMGRLLGEADG, corresponding to amino acid residues 881-896 of mouse CaValpha2delta4
-
亚型
- IgG
-
-
anti-Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 4 (CACNA2D4) (AA 934-1115) antibody
CACNA2D4 适用: 人 ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 4 (CACNA2D4) (Internal Region) antibodyCACNA2D4 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 4 (CACNA2D4) (Internal Region) antibodyCACNA2D4 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 4 (CACNA2D4) (Internal Region) antibodyCACNA2D4 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 4 (CACNA2D4) (AA 757-806) antibodyCACNA2D4 适用: 人, 小鼠, 大鼠, Cow, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 4 (CACNA2D4) (C-Term) antibodyCACNA2D4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 4 (CACNA2D4) (AA 89-118), (N-Term) antibodyCACNA2D4 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB26709 unconjugated
anti-Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 4 (CACNA2D4) (C-Term) antibodyCACNA2D4 适用: 人, 小鼠, 大鼠, 豚鼠, 马, 兔, Cow WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100
Application Dilutions Western blot wb: 1:200
-
说明
-
Negative Control: (ABIN7235012)
Blocking Peptide: (ABIN7235012)
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
-
浓度
- 1 mg/mL
-
缓冲液
- PBS pH 7.4
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
-
-
- CACNA2D4 (Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 4 (CACNA2D4))
-
别名
- CACNA2D4
-
背景
-
Voltage-dependent calcium channel subunit alpha-2/delta-4, RCD4,Voltage-gated Ca2+ (CaV) channels are ubiquitously expressed and function as Ca2+ conducting pores in the plasma membrane1. Based on their electrophysiological and pharmacological properties, Ca2+ channels have traditionally been classified into L, T, N, P, Q, and R types2. L-type calcium channels are heteromultimers composed of four independently encoded proteins, the pore-forming α1 subunit, which triggers Ca2+ flow across the membrane, and the auxiliary subunits α2δ, γ, and β3. The Ca2+ channel α2δ subunit is a heavily glycosylated protein that is encoded by a single gene and post-translationally cleaved to yield α2 and δ subunits linked by a disulfide bond with a single transmembrane segment4.The α2δ subunit regulates many functional aspects of Ca2+ channels, such as gating, regulating voltage dependent kinetics, and increasing functional channel density on the plasma membrane5. There are four proteins that comprise CaVα2δ: CaVα2δ1, CaVα2δ2, CaVα2δ3 and CaVα2δ46. CaVα2δ4 participates in the regulation of membrane expression of CaV channels. It is predominantly expressed in certain types of endocrine cells. It is also detected in the erythroblasts in the fetal liver, in the cells of the zona reticularis of the adrenal gland and in the basophiles of the pituitary. Defects in CaVα2δ4 are the cause of retinal cone dystrophy 4 (RCD4). RCD4 is characterized by minimal symptoms except for slowly progressive reduction in visual acuity7.
Alternative names: CACNA2D4 (CaValpha2delta4), Voltage-dependent calcium channel subunit alpha-2/delta-4, RCD4 -
基因ID
- 319734
-
NCBI登录号
- NM_172364
-
UniProt
- Q5RJF7
抗原
-
