CHERP 抗体 (Cytosolic)
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Quick Overview for CHERP 抗体 (Cytosolic) (ABIN7043011)
抗原
See all CHERP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 669-684, Cytosolic
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原理
- A Rabbit Polyclonal Antibody to CHERP
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rat,human - identical
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产品特性
- Anti-CHERP Antibody (ABIN7043011, ABIN7044119 and ABIN7044120) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize CHERP from human, rat, and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KLEDHEYKPLDPKDIR, corresponding to amino acid residues 669-684 of mouse CHERP
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亚型
- IgG
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anti-Calcium Homeostasis Endoplasmic Reticulum Protein (CHERP) (AA 795-883) antibody
CHERP 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2H5 unconjugated
anti-Calcium Homeostasis Endoplasmic Reticulum Protein (CHERP) antibodyCHERP 适用: 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Calcium Homeostasis Endoplasmic Reticulum Protein (CHERP) (AA 1-884) antibodyCHERP 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Calcium Homeostasis Endoplasmic Reticulum Protein (CHERP) (Middle Region) antibodyCHERP 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Calcium Homeostasis Endoplasmic Reticulum Protein (CHERP) (AA 866-916) antibodyCHERP 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Calcium Homeostasis Endoplasmic Reticulum Protein (CHERP) (AA 400-450) antibodyCHERP 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Calcium Homeostasis Endoplasmic Reticulum Protein (CHERP) (AA 650-750) antibodyCHERP 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Calcium Homeostasis Endoplasmic Reticulum Protein (CHERP) (AA 683-732) antibodyCHERP 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 斑马鱼, Bat, 小鸡, 猴, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Calcium Homeostasis Endoplasmic Reticulum Protein (CHERP) (C-Term) antibodyCHERP 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, Bat, 小鸡, 猴, 非洲爪蟾, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Calcium Homeostasis Endoplasmic Reticulum Protein (CHERP) (AA 877-903), (C-Term) antibodyCHERP 适用: 人 WB 宿主: 兔 Polyclonal RB37838 unconjugated
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应用备注
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WB: 1:1500
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235001)
Blocking Peptide: (ABIN7235001)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- CHERP (Calcium Homeostasis Endoplasmic Reticulum Protein (CHERP))
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别名
- CHERP
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背景
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Synonyms: Calcium homeostasis endoplasmic reticulum protein, SR-related CTD-associated factor 6, SCAF6
Description: CHERP (calcium homeostasis endoplasmic reticulum protein) is a ubiquitously expressed integral sarco/endoplasmic reticulum (SR/ER) membrane protein. CHERP protein consist of 916 amino acid in humans and its structure containing a Pro-rich region and a segment of Arg-Ser dipeptide repeats (an RS domain) near the C terminus, and an RNA recognition motifs (RRMs)1-3.CHERP acts as a regulator of both major families of endoplasmic reticulum Ca2+ channels, inositol 1,4,5-trisphosphate receptors (IP3Rs) and ryanodine receptors (RyRs). CHERP is responsible for the regulation of intracellular Ca2+ mobilization in human cells and is involved in neuroblastoma cell proliferation, apoptosis and tumorigenicity1,2.CHERP co-localizes with IP3 receptors throughout the cytoplasmic and perinuclear regions in human erythroleukemia cells and in Jurkat cells. CHERP is also detected in the nucleoplasm with prominent accumulation at nuclear speckles1,2. CHERP co-localizes with endogenous ryanodine receptor type 1 (RyR1) in the sarcoplasmic reticulum of rat soleus muscle. Studies of CHERP knockdown reveal decreased intracellular Ca2+ mobilization, cell growth and proliferation2,3.
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基因ID
- 27967
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NCBI登录号
- NM_006387
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UniProt
- Q8CGZ0
抗原
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