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- 抗原 See all CHERP 抗体
- CHERP (Calcium Homeostasis Endoplasmic Reticulum Protein (CHERP))
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抗原表位
- AA 669-684, Cytosolic
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适用
- 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CHERP antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- 原理
- A Rabbit Polyclonal Antibody to CHERP
- 特异性
- Cytoplasmic
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Rat,human - identical
- 产品特性
- Anti-CHERP Antibody (ABIN7043011, ABIN7044119 and ABIN7044120) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize CHERP from human, rat, and mouse samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)KLEDHEYKPLDPKDIR, corresponding to amino acid residues 669-684 of mouse CHERP
- 亚型
- IgG
- Top Product
- Discover our top product CHERP Primary Antibody
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anti-Calcium Homeostasis Endoplasmic Reticulum Protein (CHERP) antibody
CHERP 适用: 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Calcium Homeostasis Endoplasmic Reticulum Protein (CHERP) (AA 795-883) antibodyCHERP 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2H5 unconjugated
anti-Calcium Homeostasis Endoplasmic Reticulum Protein (CHERP) (AA 1-884) antibodyCHERP 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Calcium Homeostasis Endoplasmic Reticulum Protein (CHERP) (AA 650-750) antibodyCHERP 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Calcium Homeostasis Endoplasmic Reticulum Protein (CHERP) (AA 683-732) antibodyCHERP 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 斑马鱼, Bat, 小鸡, 猴, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Calcium Homeostasis Endoplasmic Reticulum Protein (CHERP) (C-Term) antibodyCHERP 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, Bat, 小鸡, 猴, 非洲爪蟾, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Calcium Homeostasis Endoplasmic Reticulum Protein (CHERP) (Middle Region) antibodyCHERP 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:1500
- 说明
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Negative Control: (ABIN7235001)
Blocking Peptide: (ABIN7235001)
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- CHERP (Calcium Homeostasis Endoplasmic Reticulum Protein (CHERP))
- 别名
- CHERP (CHERP 产品)
- 背景
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Calcium homeostasis endoplasmic reticulum protein, SR-related CTD-associated factor 6, SCAF6,CHERP (calcium homeostasis endoplasmic reticulum protein) is a ubiquitously expressed integral sarco/endoplasmic reticulum (SR/ER) membrane protein. CHERP protein consist of 916 amino acid in humans and its structure containing a Pro-rich region and a segment of Arg-Ser dipeptide repeats (an RS domain) near the C terminus, and an RNA recognition motifs (RRMs)1-3.CHERP acts as a regulator of both major families of endoplasmic reticulum Ca2+ channels, inositol 1,4,5-trisphosphate receptors (IP3Rs) and ryanodine receptors (RyRs). CHERP is responsible for the regulation of intracellular Ca2+ mobilization in human cells and is involved in neuroblastoma cell proliferation, apoptosis and tumorigenicity1,2.CHERP co-localizes with IP3 receptors throughout the cytoplasmic and perinuclear regions in human erythroleukemia cells and in Jurkat cells. CHERP is also detected in the nucleoplasm with prominent accumulation at nuclear speckles1,2. CHERP co-localizes with endogenous ryanodine receptor type 1 (RyR1) in the sarcoplasmic reticulum of rat soleus muscle. Studies of CHERP knockdown reveal decreased intracellular Ca2+ mobilization, cell growth and proliferation2,3.
Alternative names: CHERP, Calcium homeostasis endoplasmic reticulum protein, SR-related CTD-associated factor 6, SCAF6 - 基因ID
- 27967
- NCBI登录号
- NM_006387
- UniProt
- Q8CGZ0
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