CABP4 抗体 (Intracellular)
Quick Overview for CABP4 抗体 (Intracellular) (ABIN7042982)
抗原
See all CABP4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 105-120, Intracellular
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原理
- A Rabbit Polyclonal Antibody to Calcium-Binding Protein 4
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特异性
- Intracellular
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交叉反应
- 小鼠, 大鼠
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预测反应
- Rat - identical, human - 14,15 amino acid residues identical
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产品特性
- Anti-CaBP4 Antibody is directed against an epitope of mouse Calcium-binding protein 4. Anti-CaBP4 Antibody (ABIN7042982, ABIN7044210 and ABIN7044211) can be used in western blot analysis. It has been designed to recognize CaBP4 from rat, mouse and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)RTYGPLLNRMFGKDR, corresponding to amino acid residues 105-120 of mouse CaBP4
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亚型
- IgG
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anti-Calcium Binding Protein 4 (CABP4) (AA 1-170) antibody
CABP4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5G11 unconjugated
anti-Calcium Binding Protein 4 (CABP4) (AA 1-107) antibodyCABP4 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Calcium Binding Protein 4 (CABP4) (AA 1-170) antibodyCABP4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3B3 unconjugated
anti-Calcium Binding Protein 4 (CABP4) (Internal Region) antibodyCABP4 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Calcium Binding Protein 4 (CABP4) (AA 74-123) antibodyCABP4 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Calcium Binding Protein 4 (CABP4) (AA 25-74) antibodyCABP4 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Calcium Binding Protein 4 (CABP4) (N-Term) antibodyCABP4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Calcium Binding Protein 4 (CABP4) (N-Term) antibodyCABP4 适用: 人, 马, 犬 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
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说明
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Negative Control: (ABIN7234915)
Blocking Peptide: (ABIN7234915)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- CABP4 (Calcium Binding Protein 4 (CABP4))
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别名
- CABP4
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背景
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Calcium-binding protein 4,Neuronal calcium-binding proteins (CaBP1-8) belong to a subclass of the calmodulin (CaM) superfamily and regulate in particular Ca2+ channel targets in the brain and retina1.CaBP4 contains two globular domains (N- and C-lobe) that each contains a pair of EF- hand motifs connected by a central linker. The second EF-hand in CaBP4 lacks conserved residues in the binding loop and is predicted to not bind Ca2+. CaBP4 interacts structurally with the C-terminal region of CaV1.4 and this Ca2+-dependent interaction has been implicated in the modulation of voltage-dependent CaV1.4 activation2.Multiple isoforms of CaBPs are localized in different neuronal cell types and perform specialized roles in signal transduction. The CaBP4 isoform regulates voltage-gated Ca2+ channels in retinal photoreceptor cells. In the eye, CaBP4 is localized at the photoreceptor synaptic terminals in rods and cones3. CaBP4 is essential for the development and maintenance of the photoreceptor synapse, likely through functional modulation of the photoreceptor Ca2+ channels, α1F L-type voltage- dependent calcium channels (CaV1.4), and neurotransmitter release4.Mutations in both CaV1.4 and CaBP4 have been identied in patients suffering from congenital stationary night blindness type 2 (CSNB2), indicating that defects in Ca2+-dependent regulation of CaV1.4 by CaBP4 are closely associated with CSNB2. Indeed, deletion of CaBP4 in the mouse leads to a CSNB2-like phenotype5.
Alternative names: CaBP4, Calcium-binding protein 4 -
基因ID
- 73660
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NCBI登录号
- NM_001300895
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UniProt
- Q8VHC5
抗原
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