Calcitonin Receptor 抗体 (Extracellular)
Quick Overview for Calcitonin Receptor 抗体 (Extracellular) (ABIN7042978)
抗原
See all Calcitonin Receptor (CALCR) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 201-215, Extracellular
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原理
- A Rabbit Polyclonal Antibody to Calcitonin Receptor
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特异性
- 1st extracellular loop
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交叉反应
- 小鼠, 大鼠
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预测反应
- Mouse - identical, human - 14,15 amino acid residues identical
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产品特性
- Anti-Calcitonin Receptor (extracellular) Antibody is directed against an epitope of rat CT-R. Anti-Calcitonin Receptor Antibody (ABIN7042978, ABIN7044190 and ABIN7044191) can be used in western blot and live cell imaging applications. It has been designed to recognize CT-R from human, rat and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)HLVEVVPNGDLVRRD, corresponding to amino acid residues 201-215 of rat CALCR
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亚型
- IgG
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anti-Calcitonin Receptor (CALCR) (AA 42-170) antibody
CALCR 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor (CALCR) (C-Term) antibodyCALCR 适用: 人 IHC, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor (CALCR) (AA 394-474) antibodyCALCR 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2F7 unconjugated
anti-Calcitonin Receptor (CALCR) (N-Term) antibodyCALCR 适用: 人, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor (CALCR) (AA 31-120) antibodyCALCR 适用: 大鼠, 小鼠 ELISA, IF (cc), IF (p), ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor (CALCR) (AA 25-148) antibodyCALCR 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor (CALCR) (AA 34-148) antibodyCALCR 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor (CALCR) (AA 445-474) antibodyCALCR 适用: 人 WB, IHC, IF, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor (CALCR) (AA 1-474) antibodyCALCR 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor (CALCR) (AA 465-494) antibodyCALCR 适用: 人 WB, IF, FACS 宿主: 兔 Polyclonal RB22504 unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
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说明
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Negative Control: (ABIN7234900)
Blocking Peptide: (ABIN7234900)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- Calcitonin Receptor (CALCR)
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别名
- CALCR
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背景
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CALCR, CT receptor, CT-R, C1A/C1B,the calcitonin receptor (CTR) is a class B G-protein coupled receptor (GPCR) that signals via activation of cAMP and protein kinase C (PKC). It is one of 15 human class B GPCRs1,2. Apart from CTR, calcitonin receptor-like receptor (CTLR) is the only other B-class GPCR to bind calcitonin. To date, there are three known human CTR mRNA isoforms arising from alternative splicing3.Calcitonin itself is a peptide hormone that contributes to bone calcification by direct inhibition of osteoclasts which resorb the bony tissue. It is part of a six-member family that has varied functionalities. By binding to receptor activity modifying proteins (RAMPs), CTR and CTLR can form receptors to every member of the calcitonin family. For instance, RAMP1 and CTR construct the calcitonin gene-related peptide (CGRP) receptor.Both CTR and CTLR have seven transmembrane domains, an intracellular C-terminal, and an extracellular N-terminal. To activate the receptors, their N-terminal must first capture the C-terminal of the ligand and then carried to the transmembrane loops where it bestows a conformational change upon them.Besides the bone, CTR has prominent roles in the kidney, CNS, placenta, ovaries, sperm, lung, and in the brain4,5.In osteoclasts, the expression of CTRs declines with age. Interestingly, polymorphism of the CTR gene is strongly associated with decreased fracture-risk in post-menopausal women3,6.
Alternative names: Calcitonin Receptor, CALCR, CT receptor, CT-R, C1A/C1B -
基因ID
- 116506
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NCBI登录号
- NM_001742
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UniProt
- P32214
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途径
- cAMP Metabolic Process
抗原
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