BRS3 抗体 (2nd Extracellular Loop)
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Quick Overview for BRS3 抗体 (2nd Extracellular Loop) (ABIN7042966)
抗原
See all BRS3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- 2nd Extracellular Loop, AA 186-201
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原理
- A Rabbit Polyclonal Antibody to Bombesin Receptor 3
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rat,mouse - 13,16 amino acids residues identical
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产品特性
- Anti-Bombesin Receptor 3 (extracellular) Antibody is directed against a well conserved epitope of the human BB3 receptor. Anti-Bombesin Receptor 3 (extracellular) Antibody (ABIN7042966 and ABIN7043938) can be used in western blot analysis, as well as immunohistochemical and flow cytometry applications, and will recognize BRS3 from rat and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)SNVYTFRDPNKNMTFE, corresponding to amino acid residues 186-201 of human BRS3
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亚型
- IgG
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anti-Bombesin-Like Receptor 3 (BRS3) antibody
BRS3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Bombesin-Like Receptor 3 (BRS3) (Cytoplasmic Domain) antibodyBRS3 适用: 人, 小鼠, 大鼠, 猴, Cow, 犬, 豚鼠, Hamster, 马, Bat, 兔, 绵羊 ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Bombesin-Like Receptor 3 (BRS3) (Cytoplasmic Domain) antibodyBRS3 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, Hamster, 马 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Bombesin-Like Receptor 3 (BRS3) (N-Term) antibodyBRS3 适用: 人, 猴 ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Bombesin-Like Receptor 3 (BRS3) (AA 290-399) antibodyBRS3 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Bombesin-Like Receptor 3 (BRS3) (AA 239-268) antibodyBRS3 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB23054 unconjugated
anti-Bombesin-Like Receptor 3 (BRS3) (AA 161-210) antibodyBRS3 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200-1:500
FC: 5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: 1:50
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7234864)
Blocking Peptide: (ABIN7234864)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- BRS3 (Bombesin-Like Receptor 3 (BRS3))
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别名
- BRS3
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背景
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Synonyms: BB3R, BRS3
Description: Bombesin receptor 3 (BB3) is a member of a family of receptors that binds the 14 amino acid peptide bombesin. Bombesin was first isolated from frog skin and it was later established that mammalians express endogenous bombesin like peptides such as gastrin-releasing peptide (GRP) a 27 amino acid homologue and neuromedin B (NMB) a 10 amino acid homologue.1BB1 is the preferred receptor for NMB while BB2 is the preferred receptor for GRP.BB3 was the third member of the bombesin receptors family to be cloned based in its sequence similarity to BB1 and BB2.2 The affinity of BB3 for bombesin is lower than that of the BB1 and BB2 receptors as is its affinity for NMB and GRP. This suggests that the mammalian endogenous ligand for the BB3 receptor remains to be identified.All three bombesin receptors are members of the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. BB3 is coupled to a Gq/11 protein that activates phospholipase C (PLC) and leads to production of inositol 1,4,5-trisphosphate (InsP3), intracellular Ca2+ mobilization and cell growth.3The physiological function of the BB3 receptor is not clear. However, studies with BB3 receptor deficient mice have shown that the mice develop mild obesity associated with hypertension and reduced metabolic rate.4,5Finally, BB3 receptor expression has been identified in several human tumors most notably lung. BB3 is therefore considered a potential target for the development of both diagnostics and anti-cancer therapies.6
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基因ID
- 680
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NCBI登录号
- NM_001727
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UniProt
- P32247
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途径
- Feeding Behaviour
抗原
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