AVPR2 抗体 (C-Term, Intracellular)
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Quick Overview for AVPR2 抗体 (C-Term, Intracellular) (ABIN7042948)
抗原
See all AVPR2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 345-358, C-Term, Intracellular
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原理
- A Rabbit Polyclonal Antibody to Vasopressin V2 Receptor
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交叉反应
- 小鼠, 大鼠
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预测反应
- Mouse - identical, human - 9,14 amino acid residues identical
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产品特性
- Anti-Vasopressin V2 Receptor (AVPR2) Antibody is directed against an epitope of rat Arginine vasopressin receptor 2. Anti-Vasopressin V2 Receptor (AVPR2) Antibody (ABIN7042948, ABIN7045339 and ABIN7045340) can be used in western blot analysis. It has been designed to recognize V2R from rat, mouse and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- RHTTHSLGPQDESC, corresponding to amino acid residues 345-358 of rat AVPR2
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亚型
- IgG
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anti-Arginine Vasopressin Receptor 2 (AVPR2) (C-Term) antibody
AVPR2 适用: 人, 猴, Cow, 犬, 豚鼠, 绵羊 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Arginine Vasopressin Receptor 2 (AVPR2) (AA 221-271) antibodyAVPR2 适用: 人 ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Arginine Vasopressin Receptor 2 (AVPR2) antibodyAVPR2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Arginine Vasopressin Receptor 2 (AVPR2) (C-Term) antibodyAVPR2 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 兔, 绵羊, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Arginine Vasopressin Receptor 2 (AVPR2) (AA 343-377), (C-Term) antibodyAVPR2 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB52186 unconjugated
anti-Arginine Vasopressin Receptor 2 (AVPR2) (Internal Region) antibodyAVPR2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Arginine Vasopressin Receptor 2 (AVPR2) (Cytoplasmic Domain) antibodyAVPR2 适用: 人, 小鼠, 大鼠, 猴, 兔, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Arginine Vasopressin Receptor 2 (AVPR2) (C-Term) antibodyAVPR2 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Arginine Vasopressin Receptor 2 (AVPR2) (AA 65-170) antibodyAVPR2 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Cited Application: IP
Negative Control: (ABIN7234794)
Blocking Peptide: (ABIN7234794)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- AVPR2 (Arginine Vasopressin Receptor 2 (AVPR2))
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别名
- AVPR2
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背景
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Synonyms: V2R, AVPR V2, Antidiuretic hormone receptor, ADHR, Renal-type arginine vasopressin receptor, DIR3, Nephrogenic diabetes insipidus
Description: Vasopressin V2 receptor (V2R), or arginine vasopressin receptor 2 (AVPR2), is a G-protein-coupled receptor (GPCR), coupled to the stimulatory heterotrimeric GTP-binding protein, GS, that elevates intracellular cAMP through activation of adenylate cyclase1-3. Like all members, it has seven transmembrane domains, an extracellular N-terminus and intracellular C-terminal tail1.AVPR2 is expressed primarily in renal collecting ducts and loop of Henle of the kidney, but also in vascular smooth muscle, where it induces vasodilation. Its ligand is the anti-diuretic hormone (ADH), aka vasopressin, a hormone that originates from the posterior pituitary gland that has key roles in water homeostasis and in hypotension5.Vasopressin triggers a variety of receptors - V1R, V2R, V3R, oxytocin and purinergic receptors, which regulate the physiological water-balance. High levels of inflammatory factors in the blood, such as the case in sepsis, are known to down-regulate the vasopressin receptors3.Mutations in V2R that prevent the receptor from reaching and anchoring to the cell surface are responsible are detected in diabetes insipidus and heart failure4,6,7 just to name a few. Interestingly, it was found that female rats possess more V2R mRNA than male rats leading to increased urine osmolality and decreased urine volume in females compared with males - a finding which explains that clinical data according to which females are more prone to suffer from hyponatremia4. A recent study also showed that vasopressin interacts with V2R in sperm-cell membranes to enhance ion transport, over expression of the hormone reduced sperm motility, hence V2R also has an important part in male fertility8.
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基因ID
- 25108
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NCBI登录号
- NM_000054
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UniProt
- Q00788
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途径
- cAMP Metabolic Process
抗原
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