AVPR1A 抗体 (Intracellular)
Quick Overview for AVPR1A 抗体 (Intracellular) (ABIN7042946)
抗原
See all AVPR1A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 378-390, Intracellular
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原理
- A Rabbit Polyclonal Antibody to Vasopressin V1A Receptor
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特异性
- Intracellular, C-terminus
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse - identical,human - 10,13
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产品特性
- Anti-Vasopressin V1A Receptor (AVPR1A) Antibody is directed against an epitope of rat Arginine vasopressin receptor 1A. Anti-Vasopressin V1A Receptor (AVPR1A) Antibody (ABIN7042946, ABIN7045335 and ABIN7045336) can be used in western blot analysis. It has been designed to recognize V1aR from rat, mouse and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)KFAKDDSDSMSRR, corresponding to amino acid residues 378-390 of rat AVPR1A
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亚型
- IgG
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anti-Arginine Vasopressin Receptor 1A (AVPR1A) (AA 349-418) antibody
AVPR1A 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Arginine Vasopressin Receptor 1A (AVPR1A) (AA 7-52) antibodyAVPR1A 适用: 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Arginine Vasopressin Receptor 1A (AVPR1A) (AA 1-52) antibodyAVPR1A 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Arginine Vasopressin Receptor 1A (AVPR1A) (AA 1-52) antibodyAVPR1A 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 7B8 unconjugated
anti-Arginine Vasopressin Receptor 1A (AVPR1A) (AA 1-52) antibodyAVPR1A 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 7B8 unconjugated
anti-Arginine Vasopressin Receptor 1A (AVPR1A) (AA 353-383) antibodyAVPR1A 适用: 人, 小鼠 WB 宿主: 小鼠 Monoclonal 1C1 unconjugated
anti-Arginine Vasopressin Receptor 1A (AVPR1A) (AA 11-60) antibodyAVPR1A 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Arginine Vasopressin Receptor 1A (AVPR1A) (AA 1-52) antibodyAVPR1A 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Arginine Vasopressin Receptor 1A (AVPR1A) (Internal Region) antibodyVerified AVPR1A 适用: 人, 大鼠, 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Arginine Vasopressin Receptor 1A (AVPR1A) (AA 346-395) antibodyAVPR1A 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200
Application Dilutions Western blot wb: 1:400
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说明
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Negative Control: (ABIN7234786)
Blocking Peptide: (ABIN7234786)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- AVPR1A (Arginine Vasopressin Receptor 1A (AVPR1A))
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别名
- AVPR1A
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背景
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V1aR, AVPR V1a, Antidiuretic hormone receptor 1a, Vascular/hepatic-type arginine vasopressin receptor,Vasopressin (AVP), the antidiuretic hormone, is a cyclic nonapeptide involved in the homeostasis of body fluid, blood volume, vascular tone, and blood pressure. AVP also belongs to the family of vasoactive and mitogenic peptides involved in physiological and pathological cell growth and differentiation1.AVP exerts its actions through binding to specific V1A, V1B, and V2, membrane receptors coupled to distinct second messengers2. V1 AVP receptor has the typical features of a G-protein coupled transmembrane receptor with seven putative hydrophobic domains, connected by three extracellular and three intracellular loops3.V1 receptors activate phospholipases A2, C, and D, resulting in the production of inositol 1,4,5-trisphosphate (IPS) and 1,Z-diacylglycerol (DAG), the mobilization of intracellular Ca2+, the influx of extracellular Ca2+, the activation of protein kinase C, and protein phosphorylation4. V1A AVP receptors have been shown by radioligand binding techniques to be present in vascular smooth muscle cells, hepatocytes, blood platelets, lymphocytes and monocytes, type 2 pneumocytes, adrenal cortex, brain (hippocampus septum et amygdalae), reproductive organs, retinal epithelium, renal mesangial cells, and the A10, A7r5,3T3, and WRK-1 cell lines4. V1A AVP receptors mediate cell contraction and proliferation, platelet aggregation, coagulation factor release, and glycogenolysis. V1B AVP receptors are located in the anterior pituitary where they stimulate ACTH release1.
Alternative names: Vasopressin V1A Receptor (AVPR1A), V1aR, AVPR V1a, Antidiuretic hormone receptor 1a, Vascular/hepatic-type arginine vasopressin receptor -
基因ID
- 25107
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NCBI登录号
- NM_000706
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UniProt
- P30560
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途径
- Regulation of Systemic Arterial Blood Pressure by Hormones, Response to Water Deprivation, Regulation of Carbohydrate Metabolic Process
抗原
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