Aquaporin 8 抗体 (Intracellular)
Quick Overview for Aquaporin 8 抗体 (Intracellular) (ABIN7042944)
抗原
See all Aquaporin 8 (AQP8) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 14-28, Intracellular
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原理
- A Rabbit Polyclonal Antibody to Aquaporin 8 Channel
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特异性
- Intracellular, N-terminus
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预测反应
- Unlikely to recognize mouse,human samples
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产品特性
- Anti-Aquaporin 8 Antibody (ABIN7042944 and ABIN7045205) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize AQP8 from rat samples only.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)REIKGKETNMADSYH, corresponding to amino acid residues 14-28 of rat AQP8
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亚型
- IgG
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anti-Aquaporin 8 (AQP8) (AA 1-255) antibody
AQP8 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1A1 unconjugated
anti-Aquaporin 8 (AQP8) (N-Term) antibodyAQP8 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Aquaporin 8 (AQP8) (AA 50-150) antibodyAQP8 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Aquaporin 8 (AQP8) (AA 1-255) antibodyAQP8 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1F8 unconjugated
anti-Aquaporin 8 (AQP8) antibodyAQP8 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Aquaporin 8 (AQP8) (AA 129-228) antibodyAQP8 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100
Application Dilutions Western blot wb: 1:200-1:400
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说明
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Cited Application: IHC
Negative Control: (ABIN7234779)
Blocking Peptide: (ABIN7234779)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- Aquaporin 8 (AQP8)
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别名
- AQP8
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背景
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AQP8,Aquaporin 8 (AQP-8) belongs to a family of membrane proteins that allow passage of water and certain other solutes through biological membranes.1 The family is composed of 13 members (AQP-0 to AQP-12). Little is known about the function of the two newest members, AQP-11 and AQP-12.The aquaporins can be divided into two functional groups based on their permability characteristics: the aquaporins that are permeated primarily by water and include besides AQP-8, AQP-1, AQP-2, AQP4 and AQP-5, and the aquaglyceroporins that are permeated by water and other small solutes such as glycerol. This last group includes AQP-3, AQP-7, AQP-9 and AQP-10.The proteins present a conserved structure of six transmembrane domains with intracellular N- and C-termini. The functional channel is a tetramer but each subunit has a separate pore and therefore the functional channel unit, contains four pores.2AQP-8 is expressed along the gastrointestinal tract including small intestine, colon, pancreas and liver and also in other organs such as testis, lung and kidney.The physiological function of AQP-8 is not entirely clear but studies suggest that it has an important role in colonic water adsorption and hepatocyte bile formation.3,4 Interestingly, AQP-8 expression is markedly altered in gastrointestinal disorders such as ulcerative colitis and inflammatory bowel disease.5
Alternative names: Aquaporin 8, AQP8 -
基因ID
- 29172
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NCBI登录号
- NM_001169
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UniProt
- P56405
抗原
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