AQP6 抗体 (Intracellular)
Quick Overview for AQP6 抗体 (Intracellular) (ABIN7042942)
抗原
See all AQP6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 259-276, Intracellular
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原理
- A Rabbit Polyclonal Antibody to Aquaporin 6 Channel
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特异性
- Intracellular, C-terminus
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交叉反应
- 小鼠, 大鼠
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预测反应
- Mouse - 15,18 amino acid residues identical
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产品特性
- Anti-Aquaporin 6 Antibody is directed against an epitope of rat AQP6. Anti-Aquaporin 6 Antibody (ABIN7042942 and ABIN7045202) can be used in western blot and immunohistochemistry applications. It has been designed to recognize AQP6 from mouse and rat samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)EPQKKESQTNSEDTEVSV corresponding to amino acid residues 259-276 of rat AQP6
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亚型
- IgG
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anti-Aquaporin 6, Kidney Specific (AQP6) (AA 1-30) antibody
AQP6 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Aquaporin 6, Kidney Specific (AQP6) (Internal Region) antibodyAQP6 适用: 人, 大鼠, 小鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Aquaporin 6, Kidney Specific (AQP6) (AA 264-282), (C-Term) antibodyAQP6 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
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说明
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Cited Application: IHC
Negative Control: (ABIN7234771)
Blocking Peptide: (ABIN7234771)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- AQP6 (Aquaporin 6, Kidney Specific (AQP6))
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别名
- AQP6
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背景
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AQP6, AQP2L, Kidney-specific aquaporin,It has been long known that water must cross biological membranes by means other than simple diffusion. However, it was not until recently, with the discovery of the Aquaporin 1 water channel that this question was answered. The importance of this discovery was underlined by the awarding, in 2003, the Nobel Prize in Chemistry to Peter Agre for the discovery of water channels. Today, eleven mammalian proteins that belong to the Aquaporin family have been identified. The proteins present a conserved structure of six transmembrane domains with intracellular N- and C-termini.Aquaporin 6 (AQP6) appears to be exclusively expressed in the kidney, particularly in intracellular vesicles in collecting duct intercalated cells. Unlike the other aquaporins, AQP6 was found to allow permeation of anions following activation with acidic pH or Hg2+ ions. Increased expression of AQP6 was shown in models of chronic alkalosis and lithium-induced nephrogenic diabetes insipidus.
Alternative names: Aquaporin 6, AQP6, AQP2L, Kidney-specific aquaporin -
基因ID
- 29170
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UniProt
- Q9WTY0
抗原
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