Aquaporin 4 抗体 (C-Term, Intracellular)
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Quick Overview for Aquaporin 4 抗体 (C-Term, Intracellular) (ABIN7042939)
抗原
See all Aquaporin 4 (AQP4) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 300-314, C-Term, Intracellular
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原理
- A Rabbit Polyclonal Antibody to Aquaporin 4 Channel
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交叉反应
- 小鼠, 大鼠
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预测反应
- human - 13,15 amino acid residues identical,Mouse - 14
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产品特性
- Anti-Aquaporin 4 (AQP4) (300-314) Antibody (ABIN7042939, ABIN7045209 and ABIN7045210) is a highly specific antibody directed against an epitope of rat AQP4. The antibody can be used in western blot, immunohistochemistry, and immunocytochemistry applications. It has been designed to recognize the Aquaporin 4 channel from rat, mouse, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)HVIDIDRGDEKKGKD, corresponding to amino acid residues 300-314 of rat AQP4
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亚型
- IgG
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anti-Aquaporin 4 (AQP4) (AA 271-323) antibody
AQP4 适用: 人, 小鼠, 大鼠 WB, ICC, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Aquaporin 4 (AQP4) (AA 178-317) antibodyAQP4 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal C9 unconjugated
anti-Aquaporin 4 (AQP4) (AA 244-323) antibodyAQP4 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Aquaporin 4 (AQP4) (AA 295-323), (C-Term) antibodyAQP4 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Aquaporin 4 (AQP4) (AA 253-323) antibodyAQP4 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Aquaporin 4 (AQP4) antibodyMicroarray verified AQP4 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB287702 unconjugated
anti-Aquaporin 4 (AQP4) antibodyMicroarray verified AQP4 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB430199 unconjugated
anti-Aquaporin 4 (AQP4) antibodyAQP4 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 小鼠 Monoclonal unconjugated
anti-Aquaporin 4 (AQP4) (AA 247-323) antibodyAQP4 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Aquaporin 4 (AQP4) (AA 258-27) antibodyAQP4 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: 1:200
IHC: 1:200
IP: The optimal concentration should be determined by the user
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Aquaporin 4 (AQP4)
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别名
- AQP4
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背景
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Synonyms: WCH4, Mercurial-insensitive water channel
Description: Aquaporin 4 (AQP-4) belongs to a family of membrane proteins that allow passage of water and certain solutes through biological membranes. The family is composed of 13 members (AQP-0 to AQP-12).The aquaporins can be divided into two functional groups based on their permeability characteristics: the aquaporins that are only permeated by water and the aquaglyceroporins that are permeated by water and other small solutes such as glycerol. AQP-4 together with AQP-1, AQP-2 and AQP-5 belong to the first group1. Little is known about the function of the two newest members, AQP-11 and AQP-12.The proteins present a conserved structure of six transmembrane domains with intracellular N- and C-termini. The functional channel is a tetramer but each subunit has a separate pore and therefore the functional channel unit, contains four pores1.AQP-4 is the major membrane water channel in the central nervous system. The channel is expressed in astrocyte foot processes in direct contact with capillary vessels in the brain suggesting a role in water transport under normal and pathological conditions. Indeed, transgenic mice lacking AQP-4 have reduced brain swelling and improved neurological outcome following water intoxication and focal cerebral ischemia. In contrast, brain swelling and clinical outcome are worse in AQP-4-null mice in models of vasogenic (fluid leak) edema caused by freeze-injury and brain tumor, probably due to impaired AQP-4-dependent brain water clearance2.In addition, it has been recently shown that neuromyelitis optica (NMO), an inflammatory demyelinating disease that selectively affects optic nerves and spinal cord, is caused by the development of an autoantibody directed against AQP-43.
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基因ID
- 25293
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UniProt
- P47863
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途径
- Sensory Perception of Sound
抗原
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