AQP11 抗体 (Extracellular)
Quick Overview for AQP11 抗体 (Extracellular) (ABIN7042934)
抗原
See all AQP11 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 140-151, Extracellular
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原理
- A Rabbit Polyclonal Antibody to Aquaporin 11 Channel
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特异性
- 2nd extracellular loop
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交叉反应
- 小鼠, 大鼠
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交叉反应 （详细）
- Not recommended for human samples.
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预测反应
- Mouse - 11,12 amino acid residues identical
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产品特性
- Anti-Aquaporin 11 (extracellular) Antibody is directed against an extracellular epitope of rat Aquaporin 11. Anti-Aquaporin 11 (extracellular) Antibody (ABIN7042934, ABIN7045207 and ABIN7045208) can be used in western blot analysis. It has been designed to recognize AQP11 from rat and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)SLSLTKYHFDER, corresponding to amino acid residues 140-151 of rat AQP11
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亚型
- IgG
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anti-Aquaporin 11 (AQP11) (AA 244-271) antibody
AQP11 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Aquaporin 11 (AQP11) antibodyAQP11 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Aquaporin 11 (AQP11) (Internal Region) antibodyAQP11 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Aquaporin 11 (AQP11) (AA 244-271), (C-Term) antibodyAQP11 适用: 小鼠 WB, FACS 宿主: 兔 Polyclonal RB27372 unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:1000
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说明
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Negative Control: (ABIN7234755)
Blocking Peptide: (ABIN7234755)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- AQP11 (Aquaporin 11 (AQP11))
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别名
- AQP11
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背景
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AQP11,The aquaporins (AQP), also known as the major intrinsic protein superfamily (MIP), are a family of integral membrane proteins. In mammals, 13 aquaporins were described (AQP0-AQP12). Aquaporin 11 (AQP11) is a newly described member of the aquaporins family. Aquaporin 11 (AQP11) has been identified with unusual pore-forming NPA (asparagine-proline-alanine) boxes. AQP11 presents a conserved structure of six transmembrane domains with intracellular N- and C-termini. The functional channel is a tetramer but each subunit has a separate pore and therefore the functional channel unit, contains four pores1. There are two subfamilies: the aquaporins, which transport only water and the aquaglyceroporins, which transport glycerol, urea, and other small solutes in addition to water2.Aquaporins and aquaglyceroporins are ubiquitously expressed, including in the plasma membrane of renal epithelia, brain astrocytes, and red blood cells3. AQP11 is expressed in several tissues including testis, kidney, liver, and brain. In the brain, AQP11 is found in Purkinje cells, hippocampal neurons of CA1 and CA2, and cerebral cortical neurons4. In the kidney AQP11 has a central role in vesicular homeostasis as demonstrated in experiments using AQP11 knockout mice which display growth retardation and progressively die before weaning. The cause of death seems to be advanced renal failure5.
Alternative names: Aquaporin 11, AQP11 -
基因ID
- 286758
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NCBI登录号
- NM_173039
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UniProt
- Q8CHM1
抗原
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