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- 抗原 See all Anoctamin 6 (ANO6) 抗体
- Anoctamin 6 (ANO6)
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抗原表位
- AA 487-500, Extracellular
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Anoctamin 6 antibody is conjugated to FITC
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应用范围
- Flow Cytometry (FACS), Live Cell Imaging (LCI)
- 原理
- A Rabbit Polyclonal Antibody to Anoctamin-6 Conjugated to the Fluorescent Dye FITC
- 特异性
- 2nd extracellular loop
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Mouse,rat - 12,14 amino acid residues identical
- 产品特性
- Anti-Anoctamin-6 (extracellular) Antibody (ABIN7042930, ABIN7044137 and ABIN7044138)) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot, and live cell flow cytometry applications. It has been designed to recognize ANO6 from human, rat, and mouse samples. \nAnti-Anoctamin-6 (extracellular)-FITC Antibody (ABIN7042930, ABIN7044137 and ABIN7044138)-F) is directly conjugated to fluorescein isothiocyanate (FITC). The antibody can be used in immunofluorescent applications such as direct live cell flow cytometry.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)KLPKNINGTDPIQK, corresponding to amino acid residues 487-500 of human ANO6
- 亚型
- IgG
- Top Product
- Discover our top product ANO6 Primary Antibody
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anti-Anoctamin 6 (ANO6) (AA 744-824) antibody
ANO6 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Anoctamin 6 (ANO6) (AA 487-500), (Extracellular) antibodyANO6 适用: 人 WB, IF (cc), LCI 宿主: 兔 Polyclonal unconjugated
anti-Anoctamin 6 (ANO6) (AA 12-100) antibodyANO6 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Anoctamin 6 (ANO6) (AA 480-529) antibodyANO6 适用: 人, 小鼠, 大鼠, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Anoctamin 6 (ANO6) (AA 791-840) antibodyANO6 适用: 人, Cow, 兔, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Anoctamin 6 (ANO6) (AA 750-830) antibodyANO6 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Anoctamin 6 (ANO6) (Middle Region) antibodyANO6 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Anoctamin 6 (ANO6) (AA 68-96), (N-Term) antibodyANO6 适用: 人 WB 宿主: 兔 Polyclonal RB42706 unconjugated
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: N/A
- 说明
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Negative Control: RIC-001-F
Blocking Peptide: BLP-CL016
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- 50 μL double distilled water (DDW).
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- Anoctamin 6 (ANO6)
- 别名
- ANO6 (ANO6 产品)
- 背景
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ANO6, Transmembrane protein 16F, TMEM16F, Small-conductance calcium-activated nonselective cation channel, SCAN channel,Anoctamin-6 (ANO6, TMEM16F) is a member of the Anoctamin chloride channel family. This family includes 10 proteins: ANO1-ANO10 that are encoded by the conserved TMEM16A-K genes. Anoctamin-6 acts as calcium (Ca2+)-activated chloride (Cl-) channel. It generates an outwardly rectifying Cl- current when activated by a large increase in local intracellular Ca2+ concentrations1. ANO6 structure includes eight transmembrane domains and cytosolic amino- and carboxyl termini. There is a high sequence identity in the putative transmembrane domains and more divergent in other regions2,3.ANO6 has also been shown to operate as a Ca2+-activated phospholipid scramblase resulting in movement of phosphatidylserine from the inner to the outer leaflet of the plasma membrane bilayer. ANO6 is also involved in bone mineralization, cell volume regulation, cell proliferation and apoptosis1,2. ANO6 is expressed in cyst-forming epithelial cells together with ANO1.A mutation in the ANO6 gene is linked to Scott Syndrome, a rare inherited bleeding disorder, characterized by altered Ca2+-dependent platelet signaling with defective phosphatidylserine exposure and microparticle formation. Deletion of ANO6 in mice shows reduced skeleton size, skeletal deformities, and mineralization defects4,5.
Alternative names: Anoctamin-6, ANO6, Transmembrane protein 16F, TMEM16F, Small-conductance calcium-activated nonselective cation channel, SCAN channel - 基因ID
- 196527
- NCBI登录号
- NM_001025356
- UniProt
- Q4KMQ2
- 途径
- SARS-CoV-2 Protein Interactome
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